S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 19 No.2 (1978)
임신중 투여된 IMURAN이 신생흰쥐의 임파기관에 미치는 영향
Effects· of the Azathioprine Administered during Pregnancy on the Lymphoid Orga n s of the Neonatal Rats.
- 이춘식; 박재일; 장가용
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.19 No.2, pp. 54-64
- The following experiment was performed to study
the effect of azathioprine administered during pregn'
ancy on the development of lymphoid organs of neo'
The experimental animals were the three hundred
Sprague·Dawley neonatal rats which were divided into
four groups. The animals born from the azathioprine'
administered adults during pregnancy were named
for group 1 and 2. and were injected with antigen
to group 1 and saline to group 2 respectively after
birth. The animals of group 3 and 4 were born from
the adults free of azathioprine during pregnancy and
were injected with antigen to group 3 and saline to
group 4 respectively after birth.
Antigen or saline was injected intraperitoneally on
the 1st. 4th. 9th. 12th and 16th week after birth.
Then the spleen and thymus were resected on the
1st. 3rd. and 7th day after the injection for the plaque
assay and histochemical studies
The following results were obtained:
1. No plaque·forming cells and large pyroninophilic
cells were observed in the spleens of all groups on
the first week after birth
2. The number of plaque·forming cells and large
pyroninoph i1ic cells observed in the spleens was much
less after antigen injection but a little less after
saline injection in the group of azathioprine admini
stration than in the control group on the 4th. 8th
and 12th week after birth.
3. A similar number of many plaque·forming cells
and large pyroninophi1ic cells were observed in the all
groups on the 16th week after birth.
4. While the development of thymus was retMded
histologically for the groups of azathioprme acimini·
stration than the control groups until the· 8th week
after birth. a similar development of thymus between
the two groups was observed on the 12th and 16‘h
week after birth.
5. It may be suggested that adminislration of
azathioprine did interfere with the development of
T·lymphocyte and censequently affected the formation
of antibody due to the insu뻐cient collaboration between
T cells and B cells.