포도당 또는 아미노산 중복펄스후의 HGH 반응

Abstract

To determine whether high HGH responses following double pulse oral glucose administration have any influence on glucose tolerance and insulin response. and whether second pulse of intravenous glucose and oral amino acids have a physiological role in assessment of growth hormone release, 36 metabolically normal men were studied For the double pulse nutrient loads, subjects were given a second identical nutrients 3 hours after the :fi rst administration In all of three loads, in response to the second pulse, there was a predictable rise in plasma growth hormone level. In spite of higher rises in HGH, the insulin responses and glucose tolerances to the second pulse were nearly the same magnitude of the first pulse; however, slightly slower glucose disappearance shown only in the second oral glucose pulse. Early insulin response to the oral glucose was greater than the intravenous glucose. The greater increase in plasma insulin concentration with oral gluc~ ase suggested an additional stimulus to insulin secre tion possibly a release of gastrin may. to a limited extent, contribute to the non·glycemic insulin secret· Double pulse oral amino acids produced similar plasma HGH response which were certainly not less than those produced by oral glucose. However, the response was modest when glucose was infused by intravenously. How intravenous glucose restrict the HGH release remains the subject of study.