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급성일산화탄소중독이 백서신장에 미치는 영향에 관한 병리조직학적 및 효소조직화학적 연구 : Histopathologic and Enzyme Histochemical Stndies on the Effect of Acute Carbon Monoxide Poisoning in Rat Kidney
DC Field | Value | Language |
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dc.contributor.author | 송계용 | - |
dc.contributor.author | 함의근 | - |
dc.date.accessioned | 2009-09-15T14:57:11Z | - |
dc.date.available | 2009-09-15T14:57:11Z | - |
dc.date.issued | 1978-12 | - |
dc.identifier.citation | Seoul J Med, Vol.19 No.4, pp. 150-167 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/9363 | - |
dc.description.abstract | Carbon monoxide poisoning has been one of the most
serious medical problems in Korea. The frequent accidents are mainly due to the nationwide public uses of anthracite coal briquette as main domestic and industrial fuel. Recently, some of clinical observation of acute renal failure in patients of carbon monoxide poisoning were reported. An experimental study was performed to observe the effects of acute carbon monoxide poisoning on the kidney of rats , by means of histopathologic and enzyme histochemical methods, attempting to explore the mechanism behind the process of acute renal failure Experimental animals (Sprague-Dawley rats, 67 female , 210-280gm.) were devided into four groups by the duration of exposure and the conceutration of carbon monoxide; control U5 rats, unexposure). 1% CO expo (30min.) , 0.7% CO expo (12 rats, 60min.) and 0.4% CO expo (8 rats , 120 min.). Histopathologial investigation and the enzyme activities of succinic dehydrogenase (SDH) , NADH diaphorase, lactic Kidneydehydrogenase CLDH) and alkaline phosphatase CAlk. P.) in kidney were observed by hematoxylin eosin staining and appropriate enzyme histochemical stamings. The results obtained were as follows: 1) Histologic section of rat kidney in groups of 30 min and 60 min. acute poisoning with 1% and 0.7% carbon monoxide revealed moderate to marked congestion of vasa recta especially in the corticornedullary junction associated with moderate degree hydropic degeneration of collecting tubules. Mild to moderate tubular necrosis and focal regeneration were observed mainly in the distal part of proximal con、oluted tubules in the inner cortex. The group of 120 min 0.4% acute poisoning showed a case of mild tubular necrosis out of 8 animals | - |
dc.language.iso | ko | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | 급성일산화탄소중독이 백서신장에 미치는 영향에 관한 병리조직학적 및 효소조직화학적 연구 | - |
dc.title.alternative | Histopathologic and Enzyme Histochemical Stndies on the Effect of Acute Carbon Monoxide Poisoning in Rat Kidney | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Song, Kye Yong | - |
dc.contributor.AlternativeAuthor | Ham, Eui Kenn | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 167 | - |
dc.citation.number | 4 | - |
dc.citation.pages | 150-167 | - |
dc.citation.startpage | 150 | - |
dc.citation.volume | 19 | - |
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