백서 간 및 뇌 MICROSOME분획이 지질 및 효소활성의 성장에 따르는 차이

Abstract

The microsomal membranes were prepared from liver and brain tissues in two age groups of young(2-3 weeks) and adult(6-7 months) rats. The activity of microsomal g]ucose-6-phosphatase (G-6Pase) was determined and the microsomal lipid composition was analyzed by means of TLC and gas chromatography The results were discussed in special reference to age-related changes. and are summarized as follows 1. The marked difference in liver weight was observed between two age groups. showing active growing of liver tissue in young rats whereas no appreciable increase in brain weight was seen in adult rats, indicating the halt of brain tissue growth in very early stage of life. 2. The specific activity of G-6-Pase was much higher in young rat liver than in adult one and the slightly higher level of this enzyme was also observed in young rat brain. but much lesser extent than in liver. The differenee in the specific activity of the enzyme was discussed in relation to development of the tissues