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말초신경 손상에 의한 신경병증성 통증으로 유발된 쥐 뒷다리근 위축
Hindlimb Muscle Atrophy of Rat Induced by Neuropathic Pain

DC Field Value Language
dc.contributor.author최명애-
dc.contributor.author최정안-
dc.contributor.author이경숙-
dc.contributor.author안경주-
dc.contributor.author김경화-
dc.date.accessioned2009-09-16T02:55:28Z-
dc.date.available2009-09-16T02:55:28Z-
dc.date.issued2008-
dc.identifier.citationJ Korean Biol Nurs Sci, 10(1), 88-95en
dc.identifier.issn1229-6155-
dc.identifier.urihttp://uci.or.kr/G100:I100-KOI(KISTI1.1003/JNL.JAKO200809861410551)-
dc.identifier.urihttps://hdl.handle.net/10371/9403-
dc.description.abstractPurpose: The purpose of this study was to examine the effect of neuropathic pain by peripheral nerve injury on mass and Type I and II fiber cross-sectional areas on hindlimb muscles of the neuropathic pain model rat.

Methods: Adult male Sprague-Dawley rats (body weight 200-220 g) were assigned to one of two groups: a neuropathic pain group (n=7) that had a ligation of the left L5 spinal nerve, a control group (n=5), a naive rat without any procedures. Withdrawal threshold, activity, body weight and food intake were measured daily. At 8 days after neuropathic pain, all rats were anesthetized and the soleus and plantaris muscles were dissected from the both hindlimbs. Body weight, food intake, muscle weight and Type I and II fiber cross-sectional area of the dissected muscles were determined.

Results: The neuropathic pain group showed a significant decreases (p<.05) as compared with the control rats, in diet intake, body weight, muscle weight and Type II fiber cross-sectional area of the left (affected side) soleus and plantaris muscles, and the right (unaffected side) muscle weight of plantaris and Type II fiber cross-sectional area of the soleus muscle.

Conclusion: The hindlimb muscle atrophy occurs in both affected and unaffected side due to neuropathic pain by the peripheral nerve injury. The hindlimb muscle atrophy of the affected side is more pronounced than that of the unaffected side.
en
dc.description.sponsorship이 연구는 2007년도 정부(과학기술부)의 재원으로 한국과학재단의 지원을 받아 수행된 연구임(R01-2007-000-10573-0).en
dc.language.isokoen
dc.publisher대한기초간호자연과학회 = Korean Society of Biological Nursing Scienceen
dc.subject통증en
dc.subjecten
dc.subject신경손상en
dc.subject근위축en
dc.subject(Neuropathic) Painen
dc.subjectRatsen
dc.subject(peripheral) Nerve injuryen
dc.subjecthindlimb musclesen
dc.subjectMuscular atrophyen
dc.title말초신경 손상에 의한 신경병증성 통증으로 유발된 쥐 뒷다리근 위축en
dc.title.alternativeHindlimb Muscle Atrophy of Rat Induced by Neuropathic Painen
dc.typeArticleen
dc.contributor.AlternativeAuthorChoe, Myoung-Ae-
dc.contributor.AlternativeAuthorChoi, Jung-An-
dc.contributor.AlternativeAuthorLee, Kyung-Sook-
dc.contributor.AlternativeAuthorAn, Gyeong-Ju-
dc.contributor.AlternativeAuthorKim, Kyung-Hwa-
Appears in Collections:
College of Nursing (간호대학)Dept. of Nursing (간호학과)Journal Papers (저널논문_간호학과)
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