동종피부이식에 미치는 X선 전신조사의 영향

Abstract

The behavior of the homologous skin grafts in rats irradiated with sublethal dosis of X-ray was studied. Wistar albino rats were used as recipients and donors were Long-Evans hooded rats. The sublethal dosis of total body irradiation of X·ray to the normal Wistar rats was approximately 600r-650 r and 500r was estimated to be sublethal dosis. The skin homografts of 2.0cm.x 2.0 cm. from hooded donors to untreated Wister recipients survived for 7 to 10days, on average 8. 5 days, followed by the typical pattern of the skin homograft re ection; whereas of the 15sublethally irradiated ani~ mals 12showed prolonged survival (4 to weeks) of the grafts from hooded donors, which were ultimately replaced by the host tissue with the chronic rejection pattern, none of them survived permanently.