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Prevalence of Anti-Ganglioside Antibodies and Their Clinical Correlates with Guillain-Barre Syndrome in Korea: A Nationwide Multicenter Study

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dc.contributor.authorKim, Jong Kuk-
dc.contributor.authorBae, Jong Seok-
dc.contributor.authorKim, Dae-Seong-
dc.contributor.authorKusunoki, Susumu-
dc.contributor.authorKim, Jong Eun-
dc.contributor.authorKim, Ji Soo-
dc.contributor.authorPark, Young-Eun-
dc.contributor.authorPark, Ki-Jong-
dc.contributor.authorSong, Hyun Seok-
dc.contributor.authorKim, Sun Young-
dc.contributor.authorLim, Jeong-Geun-
dc.contributor.authorKim, Nam-Hee-
dc.contributor.authorSuh, Bum Chun-
dc.contributor.authorNam, Tai-Seung-
dc.contributor.authorPark, Min Su-
dc.contributor.authorChoi, Young-Chul-
dc.contributor.authorSohn, Eun Hee-
dc.contributor.authorNa, Sang-Jun-
dc.contributor.authorHuh, So Young-
dc.contributor.authorKwon, Ohyun-
dc.contributor.authorLee, Su-Yun-
dc.contributor.authorLee, Sung-Hoon-
dc.contributor.authorOh, Sun-Young-
dc.contributor.authorJeong, Seong-Hae-
dc.contributor.authorLee, Tae-Kyeong-
dc.contributor.authorKim, Dong Uk-
dc.creator김지수-
dc.date.accessioned2015-05-26T07:20:53Z-
dc.date.available2015-05-26T07:20:53Z-
dc.date.issued2014-04-
dc.identifier.citationJournal of clinical neurology, Vol.10 No.2, pp. 94-100-
dc.identifier.issn1738-6586-
dc.identifier.urihttps://hdl.handle.net/10371/94227-
dc.description.abstractBackground and Purpose No previous studies have investigated the relationship between various anti-ganglioside antibodies and the clinical characteristics of Guillain-Barre syndrome (GBS) in Korea. The aim of this study was to determine the prevalence and types of anti-ganglioside antibodies in Korean GBS patients, and to identify their clinical significance. Methods Serum was collected from patients during the acute phase of GBS at 20 university-based hospitals in Korea. The clinical and laboratory findings were reviewed and compared with the detected types of anti-ganglioside antibody. Results Among 119 patients, 60 were positive for immunoglobulin G (IgG) or immunoglobulin M antibodies against any type of ganglioside (50%). The most frequent type was IgG anti-GM1 antibody (47%), followed by IgG anti-GT1a (38%), IgG anti-GD1a (25%), and IgG anti-GQ1b (8%) antibodies. Anti-GM1-antibody positivity was strongly correlated with the presence of preceding gastrointestinal infection, absence of sensory symptoms or signs, and absence of cranial nerve involvement. Patients with anti-GD1a antibody were younger, predominantly male, and had more facial nerve involvement than the antibody-negative group. Anti-GT1a-antibody positivity was more frequently associated with bulbar weakness and was highly associated with ophthalmoplegia when coupled with the coexisting anti-GQ1b antibody. Despite the presence of clinical features of acute motor axonal neuropathy (AMAN), 68% of anti-GM1- or anti-GD1a-antibody-positive cases of GBS were diagnosed with acute inflammatory demyelinating polyradiculoneuropathy (AMP) by a single electrophysiological study. Conclusions Anti-ganglioside antibodies were frequently found in the serum of Korean GBS patients, and each antibody was correlated strongly with the various clinical manifestations. Nevertheless, without an anti-ganglioside antibody assay, in Korea AMAN is frequently misdiagnosed as AIDP by single electrophysiological studies.en
dc.language.isoenen
dc.publisherKorean Neurological Associationen
dc.subject복합학en
dc.subjectGuillain-Barré syndrome-
dc.titlePrevalence of Anti-Ganglioside Antibodies and Their Clinical Correlates with Guillain-Barre Syndrome in Korea: A Nationwide Multicenter Studyen
dc.typeArticle-
dc.contributor.AlternativeAuthor김종국-
dc.contributor.AlternativeAuthor배종석-
dc.contributor.AlternativeAuthor김대성-
dc.contributor.AlternativeAuthor김종은-
dc.contributor.AlternativeAuthor김지수-
dc.contributor.AlternativeAuthor박영은-
dc.contributor.AlternativeAuthor박기종-
dc.contributor.AlternativeAuthor송현석-
dc.contributor.AlternativeAuthor김선영-
dc.contributor.AlternativeAuthor임정근-
dc.contributor.AlternativeAuthor김남희-
dc.contributor.AlternativeAuthor서범준-
dc.contributor.AlternativeAuthor남태승-
dc.contributor.AlternativeAuthor박민수-
dc.contributor.AlternativeAuthor최영철-
dc.contributor.AlternativeAuthor손은희-
dc.contributor.AlternativeAuthor나상준-
dc.contributor.AlternativeAuthor허소영-
dc.contributor.AlternativeAuthor권오윤-
dc.contributor.AlternativeAuthor이수연-
dc.contributor.AlternativeAuthor이성훈-
dc.contributor.AlternativeAuthor오선영-
dc.contributor.AlternativeAuthor정성해-
dc.contributor.AlternativeAuthor이태경-
dc.contributor.AlternativeAuthor김동욱-
dc.identifier.doi10.3988/jcn.2014.10.2.94-
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dc.description.srndFILENAME:kimjk-anti ganlioside ab-gbs-j clin neurol-2014-10(2)94.pdf-
dc.description.srndDEPT_NM:의학과-
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dc.identifier.srnd2014-01/102/0000004487/14-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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