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Prevalence of Anti-Ganglioside Antibodies and Their Clinical Correlates with Guillain-Barre Syndrome in Korea: A Nationwide Multicenter Study
DC Field | Value | Language |
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dc.contributor.author | Kim, Jong Kuk | - |
dc.contributor.author | Bae, Jong Seok | - |
dc.contributor.author | Kim, Dae-Seong | - |
dc.contributor.author | Kusunoki, Susumu | - |
dc.contributor.author | Kim, Jong Eun | - |
dc.contributor.author | Kim, Ji Soo | - |
dc.contributor.author | Park, Young-Eun | - |
dc.contributor.author | Park, Ki-Jong | - |
dc.contributor.author | Song, Hyun Seok | - |
dc.contributor.author | Kim, Sun Young | - |
dc.contributor.author | Lim, Jeong-Geun | - |
dc.contributor.author | Kim, Nam-Hee | - |
dc.contributor.author | Suh, Bum Chun | - |
dc.contributor.author | Nam, Tai-Seung | - |
dc.contributor.author | Park, Min Su | - |
dc.contributor.author | Choi, Young-Chul | - |
dc.contributor.author | Sohn, Eun Hee | - |
dc.contributor.author | Na, Sang-Jun | - |
dc.contributor.author | Huh, So Young | - |
dc.contributor.author | Kwon, Ohyun | - |
dc.contributor.author | Lee, Su-Yun | - |
dc.contributor.author | Lee, Sung-Hoon | - |
dc.contributor.author | Oh, Sun-Young | - |
dc.contributor.author | Jeong, Seong-Hae | - |
dc.contributor.author | Lee, Tae-Kyeong | - |
dc.contributor.author | Kim, Dong Uk | - |
dc.creator | 김지수 | - |
dc.date.accessioned | 2015-05-26T07:20:53Z | - |
dc.date.available | 2015-05-26T07:20:53Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.citation | Journal of clinical neurology, Vol.10 No.2, pp. 94-100 | - |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.uri | https://hdl.handle.net/10371/94227 | - |
dc.description.abstract | Background and Purpose No previous studies have investigated the relationship between various anti-ganglioside antibodies and the clinical characteristics of Guillain-Barre syndrome (GBS) in Korea. The aim of this study was to determine the prevalence and types of anti-ganglioside antibodies in Korean GBS patients, and to identify their clinical significance. Methods Serum was collected from patients during the acute phase of GBS at 20 university-based hospitals in Korea. The clinical and laboratory findings were reviewed and compared with the detected types of anti-ganglioside antibody. Results Among 119 patients, 60 were positive for immunoglobulin G (IgG) or immunoglobulin M antibodies against any type of ganglioside (50%). The most frequent type was IgG anti-GM1 antibody (47%), followed by IgG anti-GT1a (38%), IgG anti-GD1a (25%), and IgG anti-GQ1b (8%) antibodies. Anti-GM1-antibody positivity was strongly correlated with the presence of preceding gastrointestinal infection, absence of sensory symptoms or signs, and absence of cranial nerve involvement. Patients with anti-GD1a antibody were younger, predominantly male, and had more facial nerve involvement than the antibody-negative group. Anti-GT1a-antibody positivity was more frequently associated with bulbar weakness and was highly associated with ophthalmoplegia when coupled with the coexisting anti-GQ1b antibody. Despite the presence of clinical features of acute motor axonal neuropathy (AMAN), 68% of anti-GM1- or anti-GD1a-antibody-positive cases of GBS were diagnosed with acute inflammatory demyelinating polyradiculoneuropathy (AMP) by a single electrophysiological study. Conclusions Anti-ganglioside antibodies were frequently found in the serum of Korean GBS patients, and each antibody was correlated strongly with the various clinical manifestations. Nevertheless, without an anti-ganglioside antibody assay, in Korea AMAN is frequently misdiagnosed as AIDP by single electrophysiological studies. | en |
dc.language.iso | en | en |
dc.publisher | Korean Neurological Association | en |
dc.subject | 복합학 | en |
dc.subject | Guillain-Barré syndrome | - |
dc.title | Prevalence of Anti-Ganglioside Antibodies and Their Clinical Correlates with Guillain-Barre Syndrome in Korea: A Nationwide Multicenter Study | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김종국 | - |
dc.contributor.AlternativeAuthor | 배종석 | - |
dc.contributor.AlternativeAuthor | 김대성 | - |
dc.contributor.AlternativeAuthor | 김종은 | - |
dc.contributor.AlternativeAuthor | 김지수 | - |
dc.contributor.AlternativeAuthor | 박영은 | - |
dc.contributor.AlternativeAuthor | 박기종 | - |
dc.contributor.AlternativeAuthor | 송현석 | - |
dc.contributor.AlternativeAuthor | 김선영 | - |
dc.contributor.AlternativeAuthor | 임정근 | - |
dc.contributor.AlternativeAuthor | 김남희 | - |
dc.contributor.AlternativeAuthor | 서범준 | - |
dc.contributor.AlternativeAuthor | 남태승 | - |
dc.contributor.AlternativeAuthor | 박민수 | - |
dc.contributor.AlternativeAuthor | 최영철 | - |
dc.contributor.AlternativeAuthor | 손은희 | - |
dc.contributor.AlternativeAuthor | 나상준 | - |
dc.contributor.AlternativeAuthor | 허소영 | - |
dc.contributor.AlternativeAuthor | 권오윤 | - |
dc.contributor.AlternativeAuthor | 이수연 | - |
dc.contributor.AlternativeAuthor | 이성훈 | - |
dc.contributor.AlternativeAuthor | 오선영 | - |
dc.contributor.AlternativeAuthor | 정성해 | - |
dc.contributor.AlternativeAuthor | 이태경 | - |
dc.contributor.AlternativeAuthor | 김동욱 | - |
dc.identifier.doi | 10.3988/jcn.2014.10.2.94 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2014-01/102/0000004487/14 | - |
dc.description.srnd | SEQ:14 | - |
dc.description.srnd | PERF_CD:SNU2014-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000004487 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A075641 | - |
dc.description.srnd | DEPT_CD:801 | - |
dc.description.srnd | CITE_RATE:1.807 | - |
dc.description.srnd | FILENAME:kimjk-anti ganlioside ab-gbs-j clin neurol-2014-10(2)94.pdf | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2014-01/102/0000004487/14 | - |
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