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Retrospective clinical trial of fusidic acid versus petrolatum in the postprocedure care of clean dermatologic procedures

Cited 4 time in Web of Science Cited 6 time in Scopus
Authors
Lee, Dong Hun; Kim, Dong Young; Yoon, So Young; Park, Hyun Sun; Yoon, Hyun-Sun; Cho, Soyun
Issue Date
2015-02
Publisher
Korean Dermatological Association
Citation
Annals of Dermatology, Vol.27 No.1, pp. 15-20
Keywords
의약학Dermatologic surgical proceduresFusidic acidInfectionPetrolatumWound healing
Abstract
Background: Clean dermatologic procedures create wounds with a low risk of infection (usually up to 5%). Whether the use of topical antibiotics is advocated, with regard to its efficacy and safety issues such as antibiotic resistance and sensitizing potential, is controversial. Fusidic acid, a topical antibiotic against gram-positive bacteria, is a rare sensitizer and commonly used in postprocedure care in Korea.
Objective: This is a retrospective study aimed at comparing the efficacy and safety between fusidic acid and petrolatum for the postprocedure care of clean dermatologic procedures.
Methods: Patients were treated with either fusidic acid or petrolatum ointment, applied on the wound created during clean dermatologic procedures such as biopsy of the punch, incisional, excisional, and shave types. The efficacy, adverse events, and subjective level of satisfaction were retrieved from medical records. Results: A total of 414 patients with a total of 429 wounds were enrolled. The overall rate of adverse events was 0.9%, and the rates of adverse events in the fusidic acid group and the petrolatum group were 1.4% and 0.5%, respectively (p=0.370). There was no wound discharge, pain, tenderness, swelling, induration, or dehiscence in both groups. The patients self-assessment of the wound was not significantly different between the two treatment groups.
Conclusion: Our findings support the hypothesis that the routine prophylactic use of topical antibiotics is not indicated for clean dermatologic procedures. We recommend the use of petrolatum in the postoperative care of clean dermatologic procedures because of its equivalent efficacy and superior safety profiles.
ISSN
1013-9087
Language
English
URI
https://hdl.handle.net/10371/94233
DOI
https://doi.org/10.5021/ad.2015.27.1.15
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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