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Validation of Periodontitis Screening Model Using Sociodemographic, Systemic, and Molecular Information in a Korean Population

Cited 8 time in Web of Science Cited 9 time in Scopus
Authors
Kim, Hyun-Duck; Sukhbaatar, Munkhzaya; Shin, Myungseop; Ahn, Yoo-Been; Yoo, Wook-Sung
Issue Date
2014-12
Publisher
American Academy of Periodontology
Citation
Journal of periodontology, Vol.85 No.12, pp. 1676-1683
Keywords
의약학Biological markersmass screeningmatrix
metalloproteinase
periodontitis
Abstract
Background: This study aims to evaluate and validate a periodontitis screening model that includes sociodemo-graphic, metabolic syndrome (MetS), and molecular information, including gingival crevicular fluid (GCF), matrix metalloproteinase (MMP), and blood cytokines.Methods: The authors selected 506 participants from the Shiwha-Banwol cohort: 322 participants from the 2005 cohort for deriving the screening model and 184 participants from the 2007 cohort for its validation. Periodontitis was assessed by dentists using the community periodontal index. Interleukin (IL)-6, IL-8, and tumor necrosis factor-a in blood and MMP-8, -9, and -13 in GCF were assayed using enzyme-linked immunosorbent assay. MetS was assessed by physicians using physical examination and blood laboratory data. Information about age, sex, income, smoking, and drinking was obtained by interview. Logistic regression analysis was applied to finalize the best-fitting model and validate the model using sensitivity, specificity, and c-statistics.Results: The derived model for periodontitis screening had a sensitivity of 0.73, specificity of 0.85, and c-statistic of 0.86 (P<0.001); those of the validated model were 0.64, 0.91, and 0.83 (P<0.001), respectively.Conclusions: The model that included age, sex, income, smoking, drinking, and blood and GCF biomarkers could be useful in screening for periodontitis. A future prospective study is indicated for evaluating this model's ability to predict the occurrence of periodontitis.
ISSN
0022-3492
Language
English
URI
http://hdl.handle.net/10371/94244
DOI
https://doi.org/10.1902/jop.2014.140061
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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