S-Space College of Medicine/School of Medicine (의과대학/대학원) Family Medicine (가정의학전공) Journal Papers (저널논문_가정의학전공)
Association between Cigarette Smoking History and Mortality in 36,446 Health Examinees in Korea
- Kim, Kyoungwoo; Yoo, Taiwoo; Kim, Yeonju; Choi, Ji-ho; Myung, Seung-Kwon; Park, Sang-Min; Hong, Yun-Chul; Cho, Belong; Park, Sue K.; Yoo, Keun-Young
- Issue Date
- Asian Pacific Journal of Cancer Prevention, Vol.15 No.14, pp. 5685-5689
- 의약학; Smoking; smoking cessation; mortality; preventive health services; early detection of cancer
- Background: It is well known that smoking is a preventable factor for all-cause mortality; however, it is still questionable how many years after smoking cessation that people will have reduced risk for mortality, in particular in those with a high interest in their own health. We aimed to examine the association between time since quitting smoking and total mortality among past-smokers relative to current smokers. Materials and Methods: We enrolled 36,446 health examinees that voluntarily taken with diverse health check-up packages of high cost burden in 1995-2003 and followed them till death by 2004. The history of cigarette smoking consumption was collected using a self-administrative questionnaire at the first visit time. Mortality risk by smoking cessation years was analyzed using Cox's proportional hazard model. Results: Compared to non-smokers, male smokers over 15 pack-years had higher risk for total mortality (HR=1.60, 95% CI 1.23-2.14). The mortality risk in female smokers with same pack-years was more pronounced than that in male smokers (HR=2.83, 95% CI 1.17-7.04) despite a small number of cases. Compared to current smokers, a decrease of total mortality was observed among those who ceased smoking, and inverse dose-response was found with years after cessation: RR 0.98 ( 95% CI, 0.64-1.41) (< 2 yrs), 0.60 (95% CI, 0.43-0.83) (3-9 yrs), and 0.58 (95% CI, 0.43-0.79) (>= 10 yrs). Conclusions: A reduced risk of total mortality was observed after 3 years of smoking cessation. Our findings suggest that at least 3 years of smoking cessation may contribute to reduce premature mortality among Asian men.
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