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High-Sensitivity C-Reactive Protein and Cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seounghee | - |
dc.contributor.author | Choe, Jae-Won | - |
dc.contributor.author | Kim, Hong-Kyu | - |
dc.contributor.author | Sung, Joohon | - |
dc.creator | 성주헌 | - |
dc.date.accessioned | 2015-05-27T06:55:43Z | - |
dc.date.available | 2015-05-27T06:55:43Z | - |
dc.date.issued | 2011-05 | - |
dc.identifier.citation | Journal of Epidemiology, Vol.21 No.3, pp. 161-168 | - |
dc.identifier.issn | 0917-5040 | - |
dc.identifier.uri | https://hdl.handle.net/10371/94258 | - |
dc.description.abstract | Background: High-sensitivity C-reactive protein (hs-CRP) is a commonly used inflammatory marker. The association between hs-CRP and cancer is less consistent than that between hs-CRP and cardiovascular diseases. This study explored the association between hs-CRP and cancer, using a large database of Korean health examination records.Methods: A total of 80 781 Koreans who visited the health promotion center of a general hospital were included. There were 729 cases of cancer of any primary site during a 3-year period. Subjects with a known cancer or a condition capable of affecting hs-CRP were excluded.Results: Serum hs-CRP was significantly higher in cancer cases (2.9 mg/L) than in non-cases (1.4 mg/L; P < 0.0001). With the lowest hs-CRP category (<1 mg/L) as reference, the crude odds ratios (ORs) for cancer were 1.36 (95% confidence interval [CI] = 1.16-1.62) for the second highest category (1-3 mg/L) and 2.49 (95% CI = 2.02-3.07) for the highest category (>3 mg/L), and the adjusted ORs for cancer were 1.16 (95% CI = 0.95-1.42) for the second highest category and 1.94 (95% CI = 1.51-2.51) for the highest category. After excluding cancer cases detected within I year after the check-up, the associations remained, although the reduced number of cancer cases (n = 88) attenuated the significance of the associations.Conclusions: Serum hs-CRP was positively associated with the risk of cancer, although causality cannot be inferred in this cross-sectional study. The results support the hypothesis that chronic inflammation plays a role in cancer. | en |
dc.language.iso | en | en |
dc.publisher | Japan Epidemiological Association | en |
dc.subject | 복합학 | en |
dc.subject | high-sensitivity C-reactive protein | - |
dc.subject | cancer | - |
dc.subject | inflammation | - |
dc.title | High-Sensitivity C-Reactive Protein and Cancer | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 이승희 | - |
dc.contributor.AlternativeAuthor | 최재원 | - |
dc.contributor.AlternativeAuthor | 김홍규 | - |
dc.contributor.AlternativeAuthor | 성주헌 | - |
dc.identifier.doi | 10.2188/jea.JE20100128 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2011-01/102/0000040632/2 | - |
dc.description.srnd | SEQ:2 | - |
dc.description.srnd | PERF_CD:SNU2011-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000040632 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A077602 | - |
dc.description.srnd | DEPT_CD:902 | - |
dc.description.srnd | CITE_RATE:1.858 | - |
dc.description.srnd | FILENAME:high-sensitivity c-reactive protein and cancer.pdf | - |
dc.description.srnd | DEPT_NM:보건학과 | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2011-01/102/0000040632/2 | - |
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