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High-Sensitivity C-Reactive Protein and Cancer

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dc.contributor.authorLee, Seounghee-
dc.contributor.authorChoe, Jae-Won-
dc.contributor.authorKim, Hong-Kyu-
dc.contributor.authorSung, Joohon-
dc.creator성주헌-
dc.date.accessioned2015-05-27T06:55:43Z-
dc.date.available2015-05-27T06:55:43Z-
dc.date.issued2011-05-
dc.identifier.citationJournal of Epidemiology, Vol.21 No.3, pp. 161-168-
dc.identifier.issn0917-5040-
dc.identifier.urihttps://hdl.handle.net/10371/94258-
dc.description.abstractBackground: High-sensitivity C-reactive protein (hs-CRP) is a commonly used inflammatory marker. The association between hs-CRP and cancer is less consistent than that between hs-CRP and cardiovascular diseases. This study explored the association between hs-CRP and cancer, using a large database of Korean health examination records.Methods: A total of 80 781 Koreans who visited the health promotion center of a general hospital were included. There were 729 cases of cancer of any primary site during a 3-year period. Subjects with a known cancer or a condition capable of affecting hs-CRP were excluded.Results: Serum hs-CRP was significantly higher in cancer cases (2.9 mg/L) than in non-cases (1.4 mg/L; P < 0.0001). With the lowest hs-CRP category (<1 mg/L) as reference, the crude odds ratios (ORs) for cancer were 1.36 (95% confidence interval [CI] = 1.16-1.62) for the second highest category (1-3 mg/L) and 2.49 (95% CI = 2.02-3.07) for the highest category (>3 mg/L), and the adjusted ORs for cancer were 1.16 (95% CI = 0.95-1.42) for the second highest category and 1.94 (95% CI = 1.51-2.51) for the highest category. After excluding cancer cases detected within I year after the check-up, the associations remained, although the reduced number of cancer cases (n = 88) attenuated the significance of the associations.Conclusions: Serum hs-CRP was positively associated with the risk of cancer, although causality cannot be inferred in this cross-sectional study. The results support the hypothesis that chronic inflammation plays a role in cancer.en
dc.language.isoenen
dc.publisherJapan Epidemiological Associationen
dc.subject복합학en
dc.subjecthigh-sensitivity C-reactive protein-
dc.subjectcancer-
dc.subjectinflammation-
dc.titleHigh-Sensitivity C-Reactive Protein and Canceren
dc.typeArticle-
dc.contributor.AlternativeAuthor이승희-
dc.contributor.AlternativeAuthor최재원-
dc.contributor.AlternativeAuthor김홍규-
dc.contributor.AlternativeAuthor성주헌-
dc.identifier.doi10.2188/jea.JE20100128-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2011-01/102/0000040632/2-
dc.description.srndSEQ:2-
dc.description.srndPERF_CD:SNU2011-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000040632-
dc.description.srndADJUST_YN:Y-
dc.description.srndEMP_ID:A077602-
dc.description.srndDEPT_CD:902-
dc.description.srndCITE_RATE:1.858-
dc.description.srndFILENAME:high-sensitivity c-reactive protein and cancer.pdf-
dc.description.srndDEPT_NM:보건학과-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2011-01/102/0000040632/2-
Appears in Collections:
Graduate School of Public Health (보건대학원)Dept. of Public Health (보건학과)Journal Papers (저널논문_보건학과)
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