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Prognostic Significance of HLA Class I Expressing in Gastric Carcinoma Defined by Monoclonal Anti-Pan HLA Class I Antibody, EMR8-5
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hae-Wan | - |
dc.contributor.author | Min, Soo Kee | - |
dc.contributor.author | Ju, Young-Su | - |
dc.contributor.author | Sung, Joohon | - |
dc.contributor.author | Lim, Man Sup | - |
dc.contributor.author | Yang, Dae Hyun | - |
dc.contributor.author | Lee, Bong Hwa | - |
dc.creator | 성주헌 | - |
dc.date.accessioned | 2015-05-27T06:55:45Z | - |
dc.date.available | 2015-05-27T06:55:45Z | - |
dc.date.issued | 2011-04 | - |
dc.identifier.citation | Journal of Gastrointestinal Surgery, Vol.15 No.8, pp. 1336-1343 | - |
dc.identifier.issn | 1091-255X | - |
dc.identifier.uri | https://hdl.handle.net/10371/94259 | - |
dc.description.abstract | Downregulation or loss of HLA class I molecules has been demonstrated in human cancers. The aim of this study was to assess the clinical significance of HLA class I expression in gastric cancer.Gastric cancer tissues from 189 patients were examined for expression of HLA class I heavy chain antigens by immunohistochemical staining with EMR8-5. The expression level of HLA class I of tumor cells is categorized by combining an estimate the percentage of immunoreactive cell with an estimate of the staining intensity. The relationship between HLA class I expression and clinicopathologic parameters, patient survival, and tumor recurrence were analyzed.HLA class I was downregulated in 85 (45.0%) of the gastric carcinomas. Staining revealed 104 (55.0%) tumors with strongly positive expression of HLA class I antigens, 76 (40.2%) tumors with weakly positive expression, and 9 (4.8%) tumors with negative expression. The expression of HLA class I antigen did not correlate with any other clinicopathologic parameters. Moreover, HLA class I expression was neither a risk factor for tumor recurrence nor survival.The downregulation of HLA class I expression is not associated with patient prognosis. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | 복합학 | en |
dc.subject | Gastric cancer | - |
dc.subject | Human leukocyte antigen class I | - |
dc.subject | Immunohistochemistry | - |
dc.title | Prognostic Significance of HLA Class I Expressing in Gastric Carcinoma Defined by Monoclonal Anti-Pan HLA Class I Antibody, EMR8-5 | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 이해완 | - |
dc.contributor.AlternativeAuthor | 민수기 | - |
dc.contributor.AlternativeAuthor | 주영수 | - |
dc.contributor.AlternativeAuthor | 성주헌 | - |
dc.contributor.AlternativeAuthor | 임만섭 | - |
dc.contributor.AlternativeAuthor | 양대현 | - |
dc.contributor.AlternativeAuthor | 이봉화 | - |
dc.identifier.doi | 10.1007/s11605-011-1545-3 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2011-01/102/0000040632/16 | - |
dc.description.srnd | SEQ:16 | - |
dc.description.srnd | PERF_CD:SNU2011-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000040632 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A077602 | - |
dc.description.srnd | DEPT_CD:902 | - |
dc.description.srnd | CITE_RATE:2.826 | - |
dc.description.srnd | FILENAME:prognostic significance of hla class i expressing in gastric carcinoma.pdf | - |
dc.description.srnd | DEPT_NM:보건학과 | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2011-01/102/0000040632/16 | - |
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