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Prognostic Significance of HLA Class I Expressing in Gastric Carcinoma Defined by Monoclonal Anti-Pan HLA Class I Antibody, EMR8-5

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dc.contributor.authorLee, Hae-Wan-
dc.contributor.authorMin, Soo Kee-
dc.contributor.authorJu, Young-Su-
dc.contributor.authorSung, Joohon-
dc.contributor.authorLim, Man Sup-
dc.contributor.authorYang, Dae Hyun-
dc.contributor.authorLee, Bong Hwa-
dc.creator성주헌-
dc.date.accessioned2015-05-27T06:55:45Z-
dc.date.available2015-05-27T06:55:45Z-
dc.date.issued2011-04-
dc.identifier.citationJournal of Gastrointestinal Surgery, Vol.15 No.8, pp. 1336-1343-
dc.identifier.issn1091-255X-
dc.identifier.urihttps://hdl.handle.net/10371/94259-
dc.description.abstractDownregulation or loss of HLA class I molecules has been demonstrated in human cancers. The aim of this study was to assess the clinical significance of HLA class I expression in gastric cancer.Gastric cancer tissues from 189 patients were examined for expression of HLA class I heavy chain antigens by immunohistochemical staining with EMR8-5. The expression level of HLA class I of tumor cells is categorized by combining an estimate the percentage of immunoreactive cell with an estimate of the staining intensity. The relationship between HLA class I expression and clinicopathologic parameters, patient survival, and tumor recurrence were analyzed.HLA class I was downregulated in 85 (45.0%) of the gastric carcinomas. Staining revealed 104 (55.0%) tumors with strongly positive expression of HLA class I antigens, 76 (40.2%) tumors with weakly positive expression, and 9 (4.8%) tumors with negative expression. The expression of HLA class I antigen did not correlate with any other clinicopathologic parameters. Moreover, HLA class I expression was neither a risk factor for tumor recurrence nor survival.The downregulation of HLA class I expression is not associated with patient prognosis.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subject복합학en
dc.subjectGastric cancer-
dc.subjectHuman leukocyte antigen class I-
dc.subjectImmunohistochemistry-
dc.titlePrognostic Significance of HLA Class I Expressing in Gastric Carcinoma Defined by Monoclonal Anti-Pan HLA Class I Antibody, EMR8-5en
dc.typeArticle-
dc.contributor.AlternativeAuthor이해완-
dc.contributor.AlternativeAuthor민수기-
dc.contributor.AlternativeAuthor주영수-
dc.contributor.AlternativeAuthor성주헌-
dc.contributor.AlternativeAuthor임만섭-
dc.contributor.AlternativeAuthor양대현-
dc.contributor.AlternativeAuthor이봉화-
dc.identifier.doi10.1007/s11605-011-1545-3-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2011-01/102/0000040632/16-
dc.description.srndSEQ:16-
dc.description.srndPERF_CD:SNU2011-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000040632-
dc.description.srndADJUST_YN:Y-
dc.description.srndEMP_ID:A077602-
dc.description.srndDEPT_CD:902-
dc.description.srndCITE_RATE:2.826-
dc.description.srndFILENAME:prognostic significance of hla class i expressing in gastric carcinoma.pdf-
dc.description.srndDEPT_NM:보건학과-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2011-01/102/0000040632/16-
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