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Phenotypic and Genetic Relationships between Kidney Function and Carotid Intima-Media Thickness in Koreans: The Healthy Twin Study

Cited 6 time in Web of Science Cited 6 time in Scopus
Authors
Lee, Kayoung; Sung, Joohon; Lee, Sang Cheol; Park, Seung Woo; Kim, Youn Sic; Lee, Joo Yeon; Song, Yun-Mi
Issue Date
2012-02
Publisher
Karger
Citation
Kidney and Blood Pressure Research, Vol.35 No.4, pp. 259-264
Keywords
복합학AlbuminuriaCarotid atherosclerosisGenetic variationGlomerular filtration rateRisk factor
Abstract
Background: The phenotypic and genetic relationships between carotid intima-media thickness (CIMT) and estimated glomerular filtration rate (eGFR) or urinary albumin-creatinine ratio (ACR) were evaluated in Korean twins and families. Methods: We recruited 688 participants (296 individual twins and 392 singletons, age 30-74 years) who were without myocardial infarction and stroke among participants in the Healthy Twin Study. eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. CIMT was measured using B-mode carotid ultrasound. Covariates were sex, Framingham risk scores, alcohol use, exercise, BMI, high-sensitivity C-reactive protein and triglycerides. Quantitative genetic and linear mixed analyses were performed. Results: In adjusted models there were associations between kidney function and CIMT with [beta] estimates ranging from -0.022 to -0.032 between eGFR and CIMT, and from 0.042-0.060 between ACR and CIMT. The covariate-adjusted heritabilities for eGFR, ACR and composite CIMT were 0.75, 0.32 and 0.45, respectively (p < 0.001). The adjusted genetic correlation between eGFR and CIMT was from -0.20 to -0.28 (p < 0.05), whereas there was no genetic correlation between ACR and CIMT. Conclusion: Kidney function is a surrogate marker of carotid atherosclerosis and further studies of the pleiotropic relationships between CIMT and eGFR are warranted. Copyright (C) 2012 S. Karger AG, Basel
ISSN
1420-4096
Language
English
URI
https://hdl.handle.net/10371/94265
DOI
https://doi.org/10.1159/000334415
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Graduate School of Public Health (보건대학원)Dept. of Public Health (보건학과)Journal Papers (저널논문_보건학과)
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