히스타민이 임파유통에 미치는 영향에 관한 연구

Abstract

The effect of histamine on the thoracic duct lymph flow and the disappearance of plasma albumin (T -1824 tagged) in nineteen dogs was observed. Mongrel dogs. between 10 and 20 kg in weight. were anesthetized and arterial blood pressure. central venous pressure, lymph pressure, lymph flow and the disappearance rate of plasma albumin were measured. Evans blue (0. 5 mg/cc) injections were made by the amount of 1. 0 cc/kg into right jugular vein, and then blood and lymph samples were col lected simultaneously at a programmed interval in order to measure potassium, protein and T -1824 concentrations. Histamine (l00 pg/cc) was infused slowly through the jugular vein and blood pressure was maintained at the lowered level of 80/40 mmHg for more than 30 minutes. and then T - 1824 was injected The average side pressure of lymph was 1. 3 em H20 and the average lymph flow from the thoracic duct was 0.49 ml per minute (2.34 ml/kg·hr). The mean total protein concentration of plm:n"'.a was 5.4 gm/IOO ml (albumin 3. 2. globulin 2. 2. A/G 1. 45). and that of lymph was 3.7 gm/l00 ml (albumin 2. 1. globulin 1. 6. A/G 1. 31) . The thoracic duct lymph flow increased 3.3 times after histamine injection. The disappearonce rate of the plasma tagged with T 1824 was O. 108/hr in the control group. and that of the histamine group was O. 133/hr. The half time of plasma albumin disappearance was 6.42 hours in the control group, and that of the histamine group was 5.21 hours. After histamine injection, time-concentratioD curves of lymph protein showed that the appearance tIme ιlas shortened, peak concentration reached earlier and was more elevated than in the control group. By the histamine injection total plasma protein and A/G ratio decreased due to the proportionately sharp decrease in plasma albumin, and those of lymph increased due to the increase of lymph albumin. Plasma potassium concentration revealed a slight increasing tendency after histamine injection.