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Childhood facial vitiligo: how intractable is it?

Cited 2 time in Web of Science Cited 1 time in Scopus
Issue Date
2015-04
Publisher
Wiley
Citation
Journal of the European Academy of Dermatology and Venereology, Vol.29 No.4, pp. 713-718
Keywords
의약학
Abstract
Background Following the recent elucidation of its pathogenic mechanisms involving reactive oxygen species, use of vitamins, folic acid and antioxidants as adjuvant therapy has been suggested.
Objective To evaluate the long-term outcome of childhood facial vitiligo who were treated with nutritional education, vitamin E (a-tocopherol 100–400 IU/day), folic acid (1–2 mg/day) and multivitamin intake and antioxidant cosmetics as the mainstay of treatment as well as the conventional therapies including oral, topical and/or intralesional corticosteroid, topical macrolactam, Excimer laser and epidermal graft.
Methods Medical data and photographs of 111 paediatric facial vitiligo patients who had been followed up for longer than 1 year from March 1, 2003 to June 30, 2013 were extracted from data warehouse of electric medical records. Photographic evaluation and final visual outcome assessment was performed.
Result By investigators assessment, 9% of patients demonstrated no improvement regardless of treatment modality, whereas 91% showed improvement of lesions. Among the latter, 33.3% resulted in >75% improvement; 18% in 50%– 75% improvement; 26.1% in 25%–50% improvement; and 13.5% in <25% improvement. In the final visual outcome assessment, Looking excellent was seen in 42.3%; looking very good in 30.6%; looking good in 17.1%; looking fair in 9.0%; and looking bad in 0.9%.
Conclusion Although childhood facial vitiligo is quite refractory to treatment, the long-term outcome of this condition is not dismal with conventional vitiligo therapy along with basic nutritional therapeutic regimen.
ISSN
0926-9959
Language
English
URI
https://hdl.handle.net/10371/94321
DOI
https://doi.org/10.1111/jdv.12666
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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