이뇨시의 혈당량 증가기전에 관한 실험적 연구

Abstract

The experiment was designed to determine whether hyperglycemia induced by diuresis is mediated thro ugh hypoinsulinemia Th2 changes in the concentration of serum sodium, potassium. and calcium, in the plasma glucose and insulin level, and in the urinary excretion. potass ium and calcium after an intravenous injection of furosemide were measured in five normal volunteers with or ',vithout previous diuretics administration. The results were as follows ]) The plasma glucose level increased slightly and the plas :na insulin level decreased slightly after furosemide administration in normal subjects \vithout any pretreatment, but little significant changes were noted 2> Furosemide injection resulted in a moderate inc~ rease in glucose level and a significant u t:: c r e a ~ e in insulin level in the subjects '''ith previous diuretics administration. The changes in insulin level preceeded the changes in glucose level 3) The amount of urinary sodium and potassum excretio~l during two hours after furosemide injection was larger than that of daily excretion and the greater part of diuresis was observed within sixty minutes after the injection 4) Furosemide injection did not induce any signifi• cant change in serum electrolyte concentration regardless of massive urinary excretion 5) From the above results it was postulated that diuress elicited hyper;3'lycemia was not due to a relative increase in the concentration following plasma water loss but due to the decrease in insulin secretion following potassium depletion