S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 16 No.4 (1975)
CO-SO2 혼합가스의 만성폭로가 흰쥐의 임신에 미치는 영향 : The Effects of Chronic Exposure to CO-SO2 mixed gases on the Gestation Patterns of the Rats
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.16 No.4, pp. 242-246
- Carbon Monoxide poisoning is one of the most freqtient cans싫 of accident in the World.
tn Korea immessurable number of incidences of
to poisoning occur annually due to the uses of
the coal briquette as main domestic fue l.
Many studies on acute poisoning have been reported
by toxicologist, clinician and other specialist
concerned. But on chronic poisoning, there
has been many controversy on the entity itself.
But some reported chronic effect of CO exposure
on the pregnancy and neurological changes.
Actually high pregnancy wastages was observed
by animal experiment. Another major noxious gas
contributing to air pollution is Sulfur•dioxide.
S0, is a typical irritant gas in contray to asphyxiant
nature of CO
S0, is also produced during the burning of coal
briquette. According to authors previous study,
high degree of contamination by CO & S0, was
found in kitchen, restaurantand Somf living room
in Seoul area.
Author designed this study to observe the effe
cts of chronic exposure to CO-SO, mixed gases on
the gestation patterns of the rats. 134 rats were
divided into 3 groups, one for the control, the
other for high concentration (CO, 1500 ppm , S0"
10 ppm , ) and the third for low concentration (CO,
750 ppm, S0" 5 ppm groups.)
The experimental rats were exposed to CO-SO,
mixed gas for 1 hour during 3 weeks gestation period.
The findings obtained are as follows
1. High pregnancy wastages were observed both
in high & low concentration group, 40.7% & 64.2
2. Pregnancy rate during gestation period was
reduced in accordance with the elapse of gestation
3. Lit ter size & body weight were significantly
reduced in high concentration group.
4. There is a strong evidence that S0, acts synergistically
with the effect of CO inducing pregnan
cy wastages of the experimental rats.
In summarizing above mentioned results, more
extensive studies should be continued to scrutinize
the real mechanism of chronic effect of CO-SO,
In the most of the large scale urban city throu
ghout the world. Air pollution is one of the serious
public health problem.
Synergistic effects of various pollutants are att
racting the Interest of environment scientist. Alii•
ong these academic topics, chronic effect of COS0,
mixed gas , especially in relation to the pregnancy,
should not be overlooked in terms of the