한국인의 혈청지질에 관한 연구

Abstract

There is much evidence that atherosclerosis and serum lipids concentrations are associated even though a causal relationship has not been definitely demonstrated The relative importance of the various factors which determine serum lipid levels has been a subject for study. However, for body fatness the data are meager and conflicting. The serum cholesterol, triglyceride and totallipid levels were measured and the lipoprotein fraction ratios and high·density lipoprotein cholesterol levels were observed by electrophoresis method in 37 obese, 20 overweight, 45 underweight and 116 normal weight subjects to investigate the interrelationship of serum lipids with body weight in Korean. Similar measurements and observations were made in 46 patients with cerebrovascular accident and 49 patients with hypertension. The results obtained are summarized as follow" 1. Serum cholesterol and total lipid levels showed significant correlation with relative body weight in normal male subjects, but no correlation in female normal subjects. Serum triglyceride level showed n 。 correlation with relative body weight in normal male subjects. 2. Serum cholesterol level showed significant correlation with % fat in normal male subjects, but no correlation in female subjects. Serum triglyceride and toal lipid levels showed no correlation with % fat in normal male and female subjects. 3. The mean values of serum cholesterol, triglyceride and total lipid were significantly higher in obese persons , patients with cerebrovascular accident and patients with hypertension than in normal weight subjects. 4. The mean value of serum cholesterol was signi M ficantly lower in female underweight persons and the mean value of triglyceride was significantly lower in male underweight persons than in normal weight subjects 5. The pre-p-lipoprotein fraction in obese persons, patients with cerebrovascular accident and patients with hypertension gave higher value than in normal weight subjects. 6. The a-lipoprotein fraction in underweight persons gave higher value than in normal weight subjeets. 7. The ratio of serum high-density lipoprotein choIesterol to total cholesterol in underweight subjects - 380 was high Er than in r.orma! weight εubj<ets， Lut significantly only in female subjects.