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대사성산증 유발원인에 따른 칼륨이동 : Potassium Transfer in Metabolic Acidosis of Various Origins
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김전 | - |
dc.contributor.author | 김우겸 | - |
dc.date.accessioned | 2009-09-16T09:17:11Z | - |
dc.date.available | 2009-09-16T09:17:11Z | - |
dc.date.issued | 1981-12 | - |
dc.identifier.citation | Seoul J Med, Vol.22 No.4, pp. 470-476 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/9527 | - |
dc.description.abstract | Mechanisms of the potassium transfer in metabolic
acidosis of various origins were studied in the rabbit skeletal mt엽cles. Metabolic acidosis was induced by infusion of either O. 3M hydrochloric acid, O. 6M lactic acid or 0.3M potassium chloride solutions. Intracellular pH (pH;) was measured by means of 5, 5-dimethyl-2, 4-oxazolidinedione (DMO) distribu' tion πethod. And simultaneously plasma pH and intra- and extracellular potassium ion concentrations were measured. The results obtained were as follows: 1. The normal arterial pH (pH.) was 7.39 and intracellular pH of the skeletal thuscle was 7.00. 2. In HCI and lactic acid group, pH. decreased to 7.01 and 7.03 , and pH; to 6.65 and 6.75 , respectively. Whereas in KCI group the pH. decreased t。 only 7. 11 and pH; did not decrease significantly from the control value 3. In HCI group the plasma K concentrations increased from the control value of 3. 8±0. 3 to 7.2 ±1. OmEq/1 along with the lowering of the pH•. In lactic acid group , on the other hand, the plasma K concentration did not change while the pH. remained in the range of 7.1~7. 4. However, when pH. fell lower than 7. 1 plasma K concentration increased gradually. The normal intracellular K concentration, 158±4, 159±3mEq/I, decreased to 145士5 and 154± 5 mEq/1 in HCI and lactic acid group, respectively. 4. The ratio of H;/H, decreased in order of KCI, lactic acid and HCI group, while K;/K , decreased in order of KCI, HCI and lactic acid group. Above results suggested that the mechanisms of the K transfer across the cell membrane in HCI and lactic acid groups might be different. The small but definite increment in plasma K ion concentration in lactic acidosis implied that K-H exchange mechanism might be involved partially in H transfer across the cell membranes. | - |
dc.language.iso | ko | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | 대사성산증 유발원인에 따른 칼륨이동 | - |
dc.title.alternative | Potassium Transfer in Metabolic Acidosis of Various Origins | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Kim, Jun | - |
dc.contributor.AlternativeAuthor | Kim, Woo Gyeum | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 476 | - |
dc.citation.number | 4 | - |
dc.citation.pages | 470-476 | - |
dc.citation.startpage | 470 | - |
dc.citation.volume | 22 | - |
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