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살정충제의 작용력에 관한 in vitro 실험
In Vitro Testing for Potency of Various Spermicidal Agents

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Authors
Lee, Hyo Pyo
Issue Date
1981-12
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.22 No.4, pp. 525-540
Abstract
The rapid progress and dramatic events in
the field of fertility regulation since 1960 have
prompted a reevaluation of the vaginal methods
of contraception includes a consideration not
only of the present status of the condom , diaphragm,
and spermicides, but also of their
potential for further development, increased
effectiveness, and greater acceptance. Todays
vaginal spermicides are available without a doctor
s prescription like the condom and , when
used in conjunction with the condom or diaphragm,
are highly effective.
Spermicidal substances have been in use
since pharaonic times, and form part of the
folklore of most cultures. In more recent times,
growing knowledge of cell biochemistry and of
spermatozoal metabolism has provided information
about substances that interfere with the
functional activity of this cell. This basic
approach has been paralleled by more or less
empirical work aimed at finding substances with
high spermicidal activity that are suitable for
human use. In the latter context, the work of
Baker (1935, 1937, 1939) in the 1930s, was
outstanding both for its application of scientific
experimentation to chemical contraception, and
for its success in determining the relative in
vitro activity of a large number of compounds.
Baker' s research led to the wide spread use of
phenylmercuric acetate, benzoate, and nitrate
as the active principles of contraceptive preparation(
Baker, et al 1937).
Currently, a lot of research is undertaken
for the development of more effective and harmless
vaginal spermicides. For evaluation and
approval of preparations for vaginal use vaginal
spermicides are tested in the laboratory for
their spermicidal activity in vitro. They are
also tested in laboratory animals for toxicity
and vaginal tolerance, and in humans for
vaginal tolerance, aesthetic acceptability and
clinical effectiveness.
This study was designed in order to evaluate
the spermicidal activity in vitro of various compounds
against human spermatozoa. Attempts
were also made to study the influence of several
factors on spermicidal activity, and to reappraise
the methodology used for the in vitro
testing of spermicidal agents.
ISSN
0582-6802
Language
Korean
URI
https://hdl.handle.net/10371/9533
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 22 No.4 (1981)
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