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Bacterial invasion and persistence: critical events in the pathogenesis of periodontitis?

Cited 74 time in Web of Science Cited 73 time in Scopus
Authors
Ji, S.; Choi, Y.S.; Choi, Youngnim
Issue Date
2015
Publisher
Wiley
Citation
Journal of Periodontal Research, vol.50, pp. 570-585
Keywords
microbiologyperiodontal immunologyperiodontal pathogensperiodontal risk factor
Description
This is an open access article under the terms
of the Creative Commons Attribution-
NonCommercial-NoDerivs License, which
permits use and distribution in any medium,
provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Abstract
Periodontitis is chronic inflammation of the periodontium caused by the hosts inflammatory response to plaque biofilm, which destroys tooth-supporting soft and hard tissues. Periodontitis is a complex disease that involves interactions among three main features – microbial challenge, the host immune response, and environmental and genetic risk factors – in its pathogenesis. Although periodontitis has been regarded as the result of hyperimmune or hyperinflammatory responses to plaque bacteria, recent studies indicate that periodontal pathogens are rather poor activators and/or suppressors of the host immune response. This raises the question of how periodontal pathogens cause inflammation. To resolve this issue, in the present review we propose that bacterial invasion into gingival tissue is a key event in the initiation of periodontitis and that the persistence of these bacteria within host tissue results in chronic inflammation. In support of this hypothesis, we present the ways in which microbial, environmental and genetic risk factors contribute to bacterial invasion. It is hoped that the current model will instigate active discussion and new research to complete the puzzle of this complex disease process.
Language
English
URI
https://hdl.handle.net/10371/95419
DOI
https://doi.org/10.1111/jre.12248
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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