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인삼 성분이 oxygen radical의 피부 collagen gelation에 대한 작용에 미치는 영향
Effects of ginseng components on theactions of oxygen radicals to gelation of skin collagen

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Authors
박찬웅; 임정규; 이정수
Issue Date
1984-03
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.25 No.1, pp. 45-55
Abstract
most types of cellular macromolecules. These radicals
can be formed as products from altered cellular metabolism
in certain pathologic states or by radiation
energy. Consequently, their destructive action to many
biological compounds are suggested to play roles in
tissue damage under various pathologic conditions
including aging phenomenon
Cutaneous tissue may be one of the tissues that
are constantly subject to attack of the oxygen radicals
because it has more chances to be exposed to Iadia
tion than others. Recently, degradative action of
oxygen radicals have been demonstrated on collagen
and proteoglycan which are major components of skin
tissue. Thus, the oxygen radicals in this tissue are
suggested to participate in aging as well as other
degradative changes.
In view of the recent reports showing that ginseng
components have antioxidant effect and quenching
action to an organic radical, it is of interest to see
effects of ginseng components on oxidative process
by oxygen radicals to assess their actions with regard
to their protective effects on tissue damage
In the present study, effects of ginseng components,
were observed on inhibition of gelation of skin collagen
by oxygen radicals generated by xanthine and
xanthine oxidase, and quenching effects of the components
on each oxygen radical were also observed
to elucidate their mechanism of antioxidant effect
observed in the present study.
The results were as follows.
1. Collagen gelation was inhibited by treatment
with xanthine and xanthine oxidase 2. The inhibited gelation was recovered by total
extract of ginseng. The protective effect on gelation
was observed with nonsaponin fraction , not with
saponin fraction
3. But collagen gelation and xanthine oxidase by
themselves were not affected by ginseng components
used.
4. Among the oxygen radicals suggested to be produced
in the xanthine oxidase system, total extract
showed quenching action to 'a" although the action
was not so remarkable as that of other 102 quenchers.
This effect was observed with nonsaponin fraction
The results suggest that ginseng components have
protective effect on collagen alteration induced by
oxygen radicals and this effect may be attributed to
102 quenching action of nonsaponin fraction of
gmseng
ISSN
0582-6802
Language
Korean
URI
https://hdl.handle.net/10371/9542
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 25 No.1 (1984)
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