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Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge

Cited 29 time in Web of Science Cited 33 time in Scopus
Authors
Ji, Suk; Choi, Youngnim
Issue Date
2015
Publisher
Frontiers
Citation
Frontiers in Cellular and Infection Microbiology, vol.5, Article 65
Keywords
periodontitispoint-ofcaretestingsalivabacteria-derivedbiomarkershost-derivedbiomarkers
Description
This is an open-access article distrubuted under the terms of the Creative Commons Attibution License(CC BY).
Abstract
Periodontitis is a chronic inflammation of the periodontium caused by persistent bacterial infection that leads to the breakdown of connective tissue and bone. Because the ability to reconstruct the periodontium is limited after alveolar bone loss, early diagnosis and intervention should be the primary goals of periodontal treatment. However, periodontitis often progresses without noticeable symptoms, and many patients do not seek professional dental care until the periodontal destruction progresses to the point of no return. Furthermore, the current diagnosis of periodontitis depends on time-consuming clinical measurements. Therefore, there is an unmet need for near-patient testing to diagnose periodontitis. Saliva is an optimal biological fluid to serve as a near-patient diagnostic tool for periodontitis. Recent developments in point-of-care (POC) testing indicate that a diagnostic test for periodontitis using saliva is now technically feasible. A number of promising salivary biomarkers associated with periodontitis have been reported. A panel of optimal biomarkers must be carefully selected based on the pathogenesis of periodontitis. The biggest hurdle for the POC diagnosis of periodontitis using saliva may be the process of validation in a large, diverse patient population. Therefore, we propose the organization of an International Consortium for Biomarkers of Periodontitis, which will gather efforts to identify, select, and validate salivary biomarkers for the diagnosis of periodontitis.
Language
English
URI
https://hdl.handle.net/10371/95426
DOI
https://doi.org/10.3389/fcimb.2015.00065
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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