정상 한국인의 HLA 항원 분포에 관한 연구

Abstract

The distribution pattcrn of HLA-A,B,C antigens was investigated in 105 normal healthy unrelated Korean adults. The HLA-A, B, C typing was carried out by the standard NIH technique , using trays obtained from UCLA Tissue Typing Laboratory. Gene frequencies were estimated from antigen frequencies using the formula GF=I 、I f-二AI' and haplotype frequencies and gametic associations between HLAAlB and HLA-B/C loci were calculated according to Mattiuz et a1 The data were analyzed and summarized as follows l. In normal Korean population, most frequent antigens for the HLA-A locus were A2 51. 4%, Aw24 49.5% , Aw33 23.8% and All 15.2% and for the HLA-B locus Bw51 22.9%, Bw62 21. 0%, Bw44 18.1%, Bw61 13.3% and Bw54 13.3% and for the HLA-C locus Cw3 49.5%, Cwl 37.1% and Cw4 I I. 4% in decreasing order of frequency. Antigens of very low frequeneies C1%~2%) were AI. Aw23, A29, Aw34, B8, B37, Bw38 and Bw63. HLA-A25, A28, Aw32, BI4, BI8, Bw41, Bw42, Bw45, Bw46, Bw47, Bw49, Bw50, Bw53. Bw56 and Bw57 antigens were absent. Blank gene frequencies were rather low; HLA-A locus 1. 7%, HLA-B locus 5.3%, HLC-C locus 42.8%. 2. These HLA antigen frequencies of the Korean population were quite similar to the Japanese population, but in the Korean population, frequeneies of A3, Aw30, Aw33, BI3, B27 and Bw 58 were higher and those of A26 and Bw52 were lower compared to the Japanese population. 3. The common haplotypes(per 10,000) in the Korean population were A2 Bw5!(647) , Aw33 Bw44(616) , Bw54 Cw!(690) and Bw58 C、，3(589). Significant positive gametic associations were noted for eight haplotypes(p<O. 05); Aw24 Bw52, Aw31 Bw51, Aw33 Bw44, Aw33 Bw58, Bw54 Cwl, BX Cwl, Bw58 Cw3 and Bw62 Cw4. 4. Although some differences were noted , the haplotype frequencies and the patterns of gametic associations in the Korean population were more or less similar to those of the Japanese population. Further studies are needed to confirm the genetic similarities and differences for the HLA antigen system between these two ethnic populations