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Cis-diamminedichloroplatinum 투여에 의한 흰쥐 신세뇨관 병변의 초미세구조 변화 : The Acute Nephrotoxicity of Cis-diamminedichloroplatinum in Rats. An Ultrastructural Observation
DC Field | Value | Language |
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dc.contributor.author | 최동섭 | - |
dc.contributor.author | 김용일 | - |
dc.contributor.author | 민헌기 | - |
dc.date.accessioned | 2009-09-16T10:42:13Z | - |
dc.date.available | 2009-09-16T10:42:13Z | - |
dc.date.issued | 1984-06 | - |
dc.identifier.citation | Seoul J Med, Vol.25 No.2, pp. 168-185 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/9565 | - |
dc.description.abstract | Cis'platinum(DDP)-induced acute nephrotoxicity was
made in rat to reappraise the nature of ultrastructural alterations in renal tubules. DDP was administered to Fischer rats intraperi· toneally in doses ranging from 2 to 20 mg per kg of body weight, and animals were sacrificed on the 1st, 3rd, 5th, 7th and the 9th day after injection. At the time of sacrifice the changes of the level of BUN, serum calcium and magnesium were obtai~ ned. Additional studies were carried out to evaluate the preventive or modifying effect of cis'platinum nephrotoxity by hydration, furosemide and gentamicin. L In the single dose of DDP-treated groups the BUN levels increased in proportion to the dosage of DDP, together with a tendency of low values of serum calcium. 2. The basic renal pathologic changes by administration of DDP was confined to the proximal convoluted tubules in deeper cortex at initial phase, and characterized by hydropic change and loss of brush border. By inreasing the dosage of DDP coagulation necrosis of proximal tubules followed and extended to subcapsular portion. 3. Ultrastructural change of proximal tubules was initiated by irregularity and rupture of mitochondria, together with phagosomal increase , dilatation of endo· plasmic reticulum and loss of ribosome; subsequent increase of fat droplets, rupture of cell membrane and necrobiosis followed by increasing the dosage of DDP and with time lapsε Attenuation and effacement of microvilli corresponding to loss of brush border in particular was a sensitive index of tubular damage by DDP, which was interpreted as secondary change due to damage of intracelluler respiratory system. 4. Subcutaneous injection of furosemide with pre· hydration 30 minutes before DDP administration revealed no increase in BUN levels, and renal patho' logic changes were mild. 5. Rats which received DDP with simultaneous administration of gentamicin showed the more increases of BUN 5 days after injection in comparison with the DDP-treated. group , and renal tubular changes became more extensive. | - |
dc.language.iso | ko | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | Cis-diamminedichloroplatinum 투여에 의한 흰쥐 신세뇨관 병변의 초미세구조 변화 | - |
dc.title.alternative | The Acute Nephrotoxicity of Cis-diamminedichloroplatinum in Rats. An Ultrastructural Observation | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Choi, Dong Seop | - |
dc.contributor.AlternativeAuthor | Kim, Yong Il | - |
dc.contributor.AlternativeAuthor | Min, Hun Ki | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 185 | - |
dc.citation.number | 2 | - |
dc.citation.pages | 168-185 | - |
dc.citation.startpage | 168 | - |
dc.citation.volume | 25 | - |
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