Vitamin A, BCG 및 Butylated Hydroxytoluene(BHT)가 Urethane 유발 폐선종생성에 미치는 영향에 관한 실험병리학적 연구

Abstract

An experimental study on urethane induced pulmouary adenoma was carried out to observe the inhibitory or enhancing effects of vitamin A, BCG and hutylated hydroxytoluene(BHT) in its developmen t. Experimental animal (389 ICR mice, average 10gm) were divided into 10 groups including control , tumor inhibition and enhancement groups: control group (urethane: lmg/gm body weight, 2 times/week, for 4 weeks, intraperitoneal) , tumor inhibition groups (vitamin A: 150,000unit/kg diet, 2 times/weeks, by gastric tube, BCG:l. 3 x 10' CFU, one time, subutaneous) and tumor enhancement group(BHT: O. 25mg/gm body weight, weekly, intraperitoneal) The results were as follows 1) Measuring body weights and organ weights of lung , significant differences were seen between control and experimental groups at the 24th week after urethane treatment. Compared as control. in vitamin A treated groups the body weights were significantly decreased, while the organ weights of lung were markedly increased in urethane groups, and were notably more increased in BHT and urethane combined treatment group. 2) Pulmonary adenoma with visible size on naked eye( 르 O. 5mm in diameter) was not observed until the 12th week by urethane treatment. The sizes and numbers of tumors were increased in relation to duration of time In the 24th week by urethane treatment the incidence of pulmonary adenoma was 100% in all experimental groups(single and combined treatment). No significant effects of Vitamin A, BeG and BHT were encountered on the incidence of pul monary adenoma. 3) The inhibitory effect of BCG on the growth of pulmonary adenoma was remarkably demonstrated, while the effect of vitamin A was rather week in degree. The additive effects of vitamin A and BCG in tumor inhibition were not clearly demonstrated. 4) The enhancing effect of BHT on the growth of pulmonary adenoma was not demonstrated In conclusion, the effects of vitamin A, BCG and BHT seem to be notably significant on the growth and less significant on the incidence in the develop ment of urethane induced pulmonary adenoma. The inhibitory effect on the growth seems to be more significant in BCG than in vitamin A. No additive inhibitory effects of vitamin A and BeG and enhancing effect of BHT are encountered on the growth of pulmonary adenoma.