Graves 질환에서 억제 T임파구의 동태에 관한 연구

Abstract

For the evaluation of suppressor T lymphocytes in peripheral hlood in patients with Graves' disease, the authors performed numerical count of T lymphocytes and its suhsets by monoclonal antibody (Pan T: OKT 3' cells, Helper T: OKT 4+ cells, Suppressor T: OKT Rc cells) and function test using suppressor cell removal index (SCRI) , in 33 cases of normal control and in 47 cases of Graves' disease patients. In addition, antimicrosomal antibody (AMA) and 'lntithyroglobulin antibody (ATA) tests were also performed by tanned red cell hemagglutination test kits in serum to evaluate correlationship with SCRI. The results were as follows: L Suppressor cell removal index (SCRI) in untre' lted hyperthyroid group cr. 84±L 04), euthyroid on treatment group (2. 08±L 12) and euthyroid in remission group (L 71±O. 57) were significantly lower than normal control group (3. 09±L 26) (p<O.01). The impairment of suppressor cell functions in Graves disease patients were still observed when patient became euthyroid by treatment with antithyroid <!rugs. 2. Suppressor T lymphocyte counts in percentage in untreated hyperthyroid group (25.81 ±4. 64) and euthyroid on treatment group (24. 67±3. 44) were significantly lower than normal control group (29.12 ±4.57) (hyperthyroid group: p<0.02, euthyroid on treatment group: p<O.01), however, no significant <!ifferences were observed in euthyroid patient group in remission state 3. No correlationship was observed between SCRI and AMA titer (r=-0.16). 4. No correlationship was observed between SCRI and ATA titer (r=-0.24), 5. No correlationship ￦a s observed between SCRI and T 3 RIA concentration in serum of Graves' disease patients. 6. No correlationship was observed between SCRI and OKT 8+ cell percentage (r=0.21), but if distribution of patients were divided into 4 groups by SCRI 3. 09(mean in normal control group) and OKT 8+ cells 29.1296 (mean in normal control group) , 68.296 of patients were distributed on lower SCRI and lower OKT 8+ cells group and 97.896 of patients were distributed on lower SCRI or lower OKT 8+ cells group. Number of lower SCRI group (88.790) was more than number of lower OKT8 • cells group (77. 396). Above data suggested that in Graves' disease, function and numerical count of suppressor T lymphocytes were significantly reduced than normal control , especially in function. The treated patients did not show improved suppressor cell function compared with untreated patients. Lowered suppressor cell function in Graves' disease might be a constitutional character based on an inhe· rited abnormality specific for the disease population.