흰쥐 및 토끼의 실험적 아니사키스증

Abstract

the pathogenic process and pathology due to Anisakis (type I) larvae infection in albino rats and rabbits. The larvae were collected from two kinds of marine fish, Pseudosciaena manchurica and Theragra chalco gramma , caught from the sea near the Korea Penin sula. They were artificially fed to a total of 36 rats and 20 rabbits and their migration pattern from gastrointestinal tract to other organs and distribution in host body as well as gross and microscopic changes in tissues were observed. The results obtained are as follows: 1. As early as 1 hour after infection in rats one larva was found to have penetrated into stomach wall and after 2 hours the larvae were also found from omentum. After 4~8 hours many larvae escaped from the gut and detected from abdominal cavity , abdominal wall and even liver parenchyme. The les ion in stomach wall was characterized by destruction of mucosal layer and extensive bleeding in areas adjacent to larvae 2. After 1 or 3 days in rabbits many larvae were found from stomach with their head portions embed· ded into the wall and one larva was detected from omentum. Several larvae were also found from inte' stinal wall , abdominal cavity and abdominal wall after 5 days. The larvae found from stomach wall after 7 days were entirely embedded in the wall and were moving transversely between submucosa and muscle layer causing profuse hemorrhage there. Bl ee· ding from stomach wall was more severe during 1~5 days after infection in rabbits. The lesion in stomach and abdominal walls was characterized by eosinophilic granuloma.