상피양 신경섬유종 (epithelioid neurofibroma) 1 예

Abstract

Epithelioid neurofibroma is a histological variant of neurofibroma that requires differential diagnosis with glomus tumor , lipoblastoma and skin adnexal tumor. This tumor is relatively rare and the definite diagnosis ean only be made after proper diagnostic procedures. including electron microscopy. We have experienced " case of epithelioid neurofibroma which was verified by electron microscopy and immunohistochemisty This 31 year old female came to SNU hospital because of a small movable painless mass in her back that was incidentally found. The mass was poorly drcumscribed without capsule formation and was yellowish white on cut surface. Microscopically the tumor mass was entirely composed of epithelioid cells with indistinct cytoplasmic border. Fine fibrillar pattern was noted in the cytoplasm. Electron micro· scopic examinations showed continuous basal lamina surrounding individual tumor cell, and Schwall cell· "xon complexes could often be seen, suggesting peri' pheral nerve sheath tumor. Immuno·histochemistry of the tumor , using anti S-100 protein antibody and peroxidase-antiperoxidase revealed uniformly positive reaction product in the tumor cell cytoplasm.