S-Space College of Engineering/Engineering Practice School (공과대학/대학원) Dept. of Mechanical Aerospace Engineering (기계항공공학부) Journal Papers (저널논문_기계항공공학부)
Cell research with physically modified microfluidic channels: A review
- Kim, Sun Min; Lee, Sung Hoon; Suh, Kahp Yang
- Issue Date
- Royal Society of Chemistry
- Lab Chip, 2008, 8, 1015-1023
- TOTAL ANALYSIS SYSTEMS; ON-A-CHIP; CULTURE ARRAY; POLYETHYLENE-GLYCOL; DEVICE; FLOW; SEPARATION; ADHESION; DOCKING; MICROMIXERS
- An overview of the use of physically modified microfluidic channels towards cell research is presented. The physical modification can be realized either by combining embedded physical micro/nanostructures or a topographically patterned substrate at the micro- or nanoscale inside a channel. After a brief description of the background and the importance of the physically modified microfluidic system, various fabrication methods are described based on the materials and geometries of physical structures and channels. Of many operational principles for microfluidics (electrical, magnetic, optical, mechanical, and so on), this review primarily focuses on mechanical operation principles aided by structural modification of the channels. The mechanical forces are classified into (i) hydrodynamic, (ii) gravitational, (iii) capillary, (iv) wetting, and (v) adhesion forces. Throughout this review, we will specify examples where necessary and provide trends and future directions in the field.