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Cell research with physically modified microfluidic channels: A review

Cited 127 time in Web of Science Cited 139 time in Scopus
Authors
Kim, Sun Min; Lee, Sung Hoon; Suh, Kahp Yang
Issue Date
2008
Publisher
Royal Society of Chemistry
Citation
Lab Chip, 2008, 8, 1015-1023
Keywords
TOTAL ANALYSIS SYSTEMSON-A-CHIPCULTURE ARRAYPOLYETHYLENE-GLYCOLDEVICEFLOWSEPARATIONADHESIONDOCKINGMICROMIXERS
Abstract
An overview of the use of physically modified microfluidic channels towards cell research is presented. The physical modification can be realized either by combining embedded physical micro/nanostructures or a topographically patterned substrate at the micro- or nanoscale inside a channel. After a brief description of the background and the importance of the physically modified microfluidic system, various fabrication methods are described based on the materials and geometries of physical structures and channels. Of many operational principles for microfluidics (electrical, magnetic, optical, mechanical, and so on), this review primarily focuses on mechanical operation principles aided by structural modification of the channels. The mechanical forces are classified into (i) hydrodynamic, (ii) gravitational, (iii) capillary, (iv) wetting, and (v) adhesion forces. Throughout this review, we will specify examples where necessary and provide trends and future directions in the field.
ISSN
1473-0197
Language
English
URI
http://hdl.handle.net/10371/9624
DOI
https://doi.org/10.1039/b800835c
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Mechanical Aerospace Engineering (기계항공공학부)Journal Papers (저널논문_기계항공공학부)
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