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Slow-releasing tranilast in polytetrafluoroethylene/polylactide-co-glycolide laminate delays adjustment after strabismus surgery in rabbit model
DC Field | Value | Language |
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dc.contributor.author | Lee, Min Joung | - |
dc.contributor.author | Jin, Su-Eon | - |
dc.contributor.author | Kim, Chong-Kook | - |
dc.contributor.author | Choung, Ho-Kyung | - |
dc.contributor.author | Jeoung, Jin Wook | - |
dc.contributor.author | Kim, Hwa Jung | - |
dc.contributor.author | Choe, Gheeyoung | - |
dc.contributor.author | Hwang, Jeong-Min | - |
dc.date.accessioned | 2009-09-20T09:11:03Z | - |
dc.date.available | 2009-09-20T09:11:03Z | - |
dc.date.issued | 2007-01-26 | - |
dc.identifier.citation | Invest Ophthalmol Vis Sci. 2007;48:699-704 | en |
dc.identifier.issn | 0146-0404 | - |
dc.identifier.uri | https://hdl.handle.net/10371/9669 | - |
dc.description.abstract | PURPOSE: To determine the usefulness of slow-releasing tranilast in polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate for delayed adjustable strabismus surgery. METHODS: A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After a recession of the superior rectus muscle (SRM), a PTFE/PLGA laminate containing tranilast, PTFE alone, or balanced salt solution was applied beneath and over the SRM in the PTFE/PLGA-tranilast group (group P-T), the PTFE group (group P), and the control group, respectively. Delayed adjustment was performed by a masked observer once on each SRM 3 or 5 weeks after surgery. Adjustability, adjustment lengths, forces required, and adhesion degrees were evaluated. RESULTS: In the control group, adjustment was impossible in any eye 3 or 5 weeks after surgery. In group P, adjustment was possible in 5 of 8 eyes 3 weeks after surgery and in 5 of 10 eyes 5 weeks after surgery. In group P-T, adjustment was possible in 8 of 10 eyes 3 and 5 weeks after surgery. On comparing adjustability, a significant difference was observed between group P-T and the control group 3 and 5 weeks after surgery (P = 0.006, P = 0.006, respectively). A significant difference was observed between group P-T and the control group (P = 0.016) in terms of adhesion between SRMs and conjunctivae 5 weeks after surgery. CONCLUSIONS: Slow-releasing tranilast in PTFE/PLGA was found to reduce adhesion and allowed delayed adjustment in most eyes for up to 5 weeks after surgery. | en |
dc.language.iso | en | - |
dc.publisher | Association for Research in Vision and Ophthalmology (ARVO) | en |
dc.title | Slow-releasing tranilast in polytetrafluoroethylene/polylactide-co-glycolide laminate delays adjustment after strabismus surgery in rabbit model | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이민정 | - |
dc.contributor.AlternativeAuthor | 진수언 | - |
dc.contributor.AlternativeAuthor | 김종국 | - |
dc.contributor.AlternativeAuthor | 정호경 | - |
dc.contributor.AlternativeAuthor | 정진욱 | - |
dc.contributor.AlternativeAuthor | 김화정 | - |
dc.contributor.AlternativeAuthor | 최기영 | - |
dc.contributor.AlternativeAuthor | 황정민 | - |
dc.identifier.doi | 10.1167/iovs.06-0775 | - |
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