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Shape changes of the corpus callosum in abstinent methamphetamine users

Cited 29 time in Web of Science Cited 29 time in Scopus
Authors
Oh, Jung Su; Lyoo, In Kyoon; Sung, Young Hoon; Hwang, Jaeuk; Kim, Jihyun; Chung, Ain; Park, Kwang Suk; Kim, Seog Ju; Renshaw, Perry F
Issue Date
2005-05-26
Publisher
Elsevier
Citation
Neurosci. Lett. 387 (2005) 76-81
Keywords
MethamphetamineCorpus callosumShape analysis
Abstract
The objective of the current study was to evaluate structural changes of the corpus callosum (CC) in abstinence methamphetamine (MA) users. Shape and size of the CC in 27 MA users were compared to those of 18 healthy comparison subjects. To define the local curvature and width of the CC, medial model-based shape analysis was performed using CC skeletons extracted from a distance map. To define the local displacement of the CC, a boundary model-based shape analysis was performed. In addition, the size of regional areas of the CC was measured according to the Witelson's definition for comparison. In the medial model-based shape analysis, increased curvature in the genu (curvature angle difference = 4.1 degrees) and decreased width in posterior midbody (width difference = 0.77 mm) and isthmus area (width difference = 0.86 mm) of the CC were observed in MA users relative to healthy comparison subjects. In the boundary model-based shape analysis, significant displacement was observed in MA users where there were differences in shape/width patterns by the medial model-based shape analysis. There were no differences in the size of regional areas of the CC between groups. Findings suggest that MA use is associated with regional changes in interhemispheric white matter tracts, which connect frontal and parietal cortices and that these frontal and parietal abnormalities may underlie clinical manifestations of the MA abuse.
ISSN
0304-3940
Language
English
URI
http://hdl.handle.net/10371/9701
DOI
https://doi.org/10.1016/j.neulet.2005.04.082
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College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
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