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Expression of gastrin and its receptor in human gastric cancer tissues
DC Field | Value | Language |
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dc.contributor.author | Hur, Keun | - |
dc.contributor.author | Kwak, Mi Kyung | - |
dc.contributor.author | Lee, Hyuk-Joon | - |
dc.contributor.author | Park, Do Joong | - |
dc.contributor.author | Lee, Hyeon Kook | - |
dc.contributor.author | Lee, Hye Seung | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.contributor.author | Michaeli, Dov | - |
dc.contributor.author | Yang, Han-Kwang | - |
dc.date.accessioned | 2009-09-25 | - |
dc.date.available | 2009-09-25 | - |
dc.date.issued | 2005-10-14 | - |
dc.identifier.citation | J Cancer Res Clin Oncol 132:85-91 | en |
dc.identifier.issn | 0171-5216 (print) | - |
dc.identifier.issn | 1432-1335 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/9810 | - |
dc.description.abstract | PURPOSE: Gastrin is a growth factor of cancerous and normal cells of the gastrointestinal tract, and its effect is known to be mediated by gastrin/cholecystokinin B (CCKB) receptor. This study was performed to investigate the prognostic significance and the expression profiles of gastrin and gastrin receptor in human gastric carcinoma tissues. METHODS: We analyzed the expressions of gastrin and gastrin receptor by immunohistochemical staining using anti-gastrin Ab (Sigma, St. Louis, MO, USA) and anti-gastrin receptor Ab (Aphton Corp., Woodland, CA, USA) in 279 gastric adenocarcinoma patients. Patients' clinicopathologic features and prognoses were analyzed. RESULTS: The gastrin expression rate in these patients was 47.7% (133/279) and the gastrin receptor expression rate was 56.5% (158/279). Gastrin expression was significantly higher in men than in women (54.3% vs. 34.1%), and higher in differentiated gastric adenocarcinoma than in the undifferentiated type (55.1% vs. 43.0%). The gastrin receptor expression rate was also significantly higher in men than in women (61.2% vs. 47.3%), and was higher in the differentiated type than in the undifferentiated type (72.9% vs. 46.5%), and significantly higher in the intestinal type than in the diffuse type (75.2% vs. 42.9%). Gastrin and gastrin/CCKB receptor expressions were not found to be significant prognostic factors in themselves. When focused on correlation between the co-expression of gastrin and gastrin/CCKB receptor and the survival, the prognosis of patients positive for both gastrin and gastrin receptor was significantly poorer than for those negative for gastrin and gastrin receptor in diffuse-type gastric cancer patients. However, multivariate analysis showed that only TNM stage was an independent prognostic factor of survival in diffuse-type gastric cancer patients. CONCLUSIONS: This study shows that the expression rates of gastrin and gastrin receptor are high (about a half) in gastric carcinoma tissues, and that there is an association between gastrin and gastrin receptor expression. We also found that patients with diffuse-type gastric carcinoma tissues expressing both gastrin and gastrin receptor have a poorer prognosis than those negative for both, which suggests that gastrin acts as an autocrine growth factor in a subgroup of gastric carcinomas. | en |
dc.description.sponsorship | This work was supported by the 21C Frontier
Functional Human Genome Project of the Korean Ministry of Science and Technology (Grant no. FG03-11-02). | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Gastrin | en |
dc.subject | Gastrin/CCKB receptor | en |
dc.subject | Gastric cancer | en |
dc.subject | Immunohistochemistry | en |
dc.title | Expression of gastrin and its receptor in human gastric cancer tissues | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 허근 | - |
dc.contributor.AlternativeAuthor | 곽미경 | - |
dc.contributor.AlternativeAuthor | 이혁준 | - |
dc.contributor.AlternativeAuthor | 박도중 | - |
dc.contributor.AlternativeAuthor | 이현국 | - |
dc.contributor.AlternativeAuthor | 이혜승 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
dc.contributor.AlternativeAuthor | 양한광 | - |
dc.identifier.doi | 10.1007/s00432-005-0043-y | - |
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