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Effect of chronic hypoxia on proliferation, apoptosis, and HSP70 expression in mouse bronchiolar epithelial cells

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dc.contributor.authorKim, E. K.-
dc.contributor.authorPark, J. D.-
dc.contributor.authorShim, S. Y.-
dc.contributor.authorKim, H. S.-
dc.contributor.authorKim, B. I.-
dc.contributor.authorChoi, J. H.-
dc.contributor.authorKim, J. E.-
dc.date.accessioned2009-09-25-
dc.date.available2009-09-25-
dc.date.issued2005-10-17-
dc.identifier.citationPhysiol Res 55: 405-411, 2006en
dc.identifier.issn0862-8408-
dc.identifier.urihttp://hdl.handle.net/10371/9815-
dc.description.abstractHeat shock proteins (HSPs) can be induced by various stresses and play an important role in cell cycle progression. HSP70 has been shown to act as an inhibitor of apoptosis. We studied HSP70 expression in bronchial epithelial cells of C57BL/6 mice and homozygous HPS70 knockout mice (hsp70.1-/-) exposed to chronic hypoxic stress. We also investigated changes in cellular proliferation and apoptosis in relation to HSP70. Lungs were removed from mice after a three-week period of exposure to 10 % O(2). Immunoblots for HSP70 and immunohistochemical staining for HSP70 and Ki-67 were performed. Apoptosis was assessed using the TUNEL assay. The three-week period of hypoxic stress did not change HSP70 levels in total lung tissue, but a significant reduction in HSP70 expression was observed in bronchiolar epithelial cells. In wild type mice, both HSP70 and Ki-67 expression were significantly reduced in bronchiolar epithelial cells. In homozygous HPS70 knockout mice (hsp70.1-/-), apoptosis of bronchiolar epithelial cells was significantly increased. Our results suggest that HSP70 may exert anti-apoptotic effects in mouse bronchiolar epithelial cells.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectChronic hypoxiaen
dc.subjectBronchiolar epitheliumen
dc.subjectHSP70en
dc.subjectProliferationen
dc.subjectApoptosisen
dc.titleEffect of chronic hypoxia on proliferation, apoptosis, and HSP70 expression in mouse bronchiolar epithelial cellsen
dc.typeArticleen
dc.contributor.AlternativeAuthor김이경-
dc.contributor.AlternativeAuthor박준동-
dc.contributor.AlternativeAuthor심소연-
dc.contributor.AlternativeAuthor김한석-
dc.contributor.AlternativeAuthor김병일-
dc.contributor.AlternativeAuthor최정환-
dc.contributor.AlternativeAuthor김지은-
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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