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Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sung-Shin | - |
dc.contributor.author | Kim, Yong-Nyun | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Kim, Young A | - |
dc.contributor.author | Kim, Ji Eun | - |
dc.contributor.author | Kim, Heejung | - |
dc.contributor.author | Kim, Chul Woo | - |
dc.date.accessioned | 2009-10-08T22:47:17Z | - |
dc.date.available | 2009-10-08T22:47:17Z | - |
dc.date.issued | 2005-05-10 | - |
dc.identifier.citation | Cancer Chemother Pharmacol 56:271. | en |
dc.identifier.issn | 0344-5704 (print) | - |
dc.identifier.issn | 1432-0843 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/10349 | - |
dc.description.abstract | More than half of anaplastic large-cell lymphoma
(ALCL) are associated with chromosomal translocation t(2;5)(p23;q35) that leads to the expression of nucleophosmin-anaplastic lymphoma kinase (NPMALK) oncoprotein. NPM-ALK activates the antiapoptotic phosphatidylinositol-3 kinase/Akt (PI3K/Akt) signaling pathway, which plays a critical role in cell survival and apoptosis. Inhibition of the PI3K/Akt pathway has been considered as a therapeutic target for cancer where PI3K/Akt activation is a causative factor. Genistein, a natural isoflavonoid found in soy products, has been shown to inhibit cell growth and induce apoptosis in a wide variety of cell lines. Here, we demonstrated that treatment of two t(2;5) ALCL cell lines, SUDHL-1 and Karpas299, with genistein induced apoptosis in a time- and dose-dependent manner. Concurrently, these cells exhibited a decrease in Akt protein levels and subsequent downregulation of Akt activity (Akt phosphorylation). Furthermore, genistein treatment induced mitochondrial membrane potential change, caspase-3 activation and PARP cleavage. From these results, we conclude that inhibition of the Akt signaling pathway and induction of apoptosis by genistein could be used as a new treatment modality for the prevention and/or treatment of t(2;5) ALCL and other hematopoietic malignancies. | en |
dc.description.sponsorship | This work was supported by the Korea Science and Engineering
Foundation (KOSEF) through the Tumor Immunity Medical Research Center (TIMRC) of Seoul National University College of Medicine. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Anaplastic large cell lymphoma | en |
dc.subject | Genistein | en |
dc.subject | Apoptosis | en |
dc.subject | Akt | en |
dc.subject | Caspase | en |
dc.title | Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박성신 | - |
dc.contributor.AlternativeAuthor | 김용년 | - |
dc.contributor.AlternativeAuthor | 전윤경 | - |
dc.contributor.AlternativeAuthor | 김용아 | - |
dc.contributor.AlternativeAuthor | 김지은 | - |
dc.contributor.AlternativeAuthor | 김희정 | - |
dc.contributor.AlternativeAuthor | 김철우 | - |
dc.identifier.doi | 10.1007/s00280-004-0974-z | - |
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