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Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma

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dc.contributor.authorPark, Sung-Shin-
dc.contributor.authorKim, Yong-Nyun-
dc.contributor.authorJeon, Yoon Kyung-
dc.contributor.authorKim, Young A-
dc.contributor.authorKim, Ji Eun-
dc.contributor.authorKim, Heejung-
dc.contributor.authorKim, Chul Woo-
dc.date.accessioned2009-10-08T22:47:17Z-
dc.date.available2009-10-08T22:47:17Z-
dc.date.issued2005-05-10-
dc.identifier.citationCancer Chemother Pharmacol 56:271.en
dc.identifier.issn0344-5704 (print)-
dc.identifier.issn1432-0843 (online)-
dc.identifier.urihttp://hdl.handle.net/10371/10349-
dc.description.abstractMore than half of anaplastic large-cell lymphoma
(ALCL) are associated with chromosomal
translocation t(2;5)(p23;q35) that leads to the expression
of nucleophosmin-anaplastic lymphoma kinase (NPMALK)
oncoprotein. NPM-ALK activates the antiapoptotic
phosphatidylinositol-3 kinase/Akt (PI3K/Akt) signaling
pathway, which plays a critical role in cell
survival and apoptosis. Inhibition of the PI3K/Akt
pathway has been considered as a therapeutic target for
cancer where PI3K/Akt activation is a causative factor.
Genistein, a natural isoflavonoid found in soy products,
has been shown to inhibit cell growth and induce
apoptosis in a wide variety of cell lines. Here, we demonstrated
that treatment of two t(2;5) ALCL cell lines,
SUDHL-1 and Karpas299, with genistein induced
apoptosis in a time- and dose-dependent manner. Concurrently,
these cells exhibited a decrease in Akt protein
levels and subsequent downregulation of Akt activity
(Akt phosphorylation). Furthermore, genistein treatment
induced mitochondrial membrane potential
change, caspase-3 activation and PARP cleavage. From
these results, we conclude that inhibition of the Akt
signaling pathway and induction of apoptosis by genistein
could be used as a new treatment modality for the
prevention and/or treatment of t(2;5) ALCL and other
hematopoietic malignancies.
en
dc.description.sponsorshipThis work was supported by the Korea Science and Engineering
Foundation (KOSEF) through the Tumor Immunity Medical Research
Center (TIMRC) of Seoul National University College of
Medicine.
en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectAnaplastic large cell lymphomaen
dc.subjectGenisteinen
dc.subjectApoptosisen
dc.subjectAkten
dc.subjectCaspaseen
dc.titleGenistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphomaen
dc.typeArticleen
dc.contributor.AlternativeAuthor박성신-
dc.contributor.AlternativeAuthor김용년-
dc.contributor.AlternativeAuthor전윤경-
dc.contributor.AlternativeAuthor김용아-
dc.contributor.AlternativeAuthor김지은-
dc.contributor.AlternativeAuthor김희정-
dc.contributor.AlternativeAuthor김철우-
dc.identifier.doi10.1007/s00280-004-0974-z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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