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G-CSF protects human cerebral hybrid neurons against in vitro ischemia

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Authors
Jung, Keun-Hwa; Chu, Kon; Lee, Soon-Tae; Kang, Lami; Kim, Seung U.; Kim, Manho; Roh, Jae-Kyu
Issue Date
2006
Publisher
Elsevier
Citation
Neurosci. Lett. 394 (2006) 168-173
Keywords
G-CSFIschemiaNeuronal deathNeuroprotectionG-CSFRSTAT3
Abstract
Granulocyte colony-stimulating factor (G-CSF) protects neurons against experimental focal cerebral ischemia. However, its neuroprotective effect on human brain is unknown. We sought to determine whether G-CSF can protect the human cerebral neurons in vitro. Human cerebral-neuroblastoma hybrid cell line (A1) was exposed to oxygen and glucose deprivation with or without G-CSF. G-CSF promoted cell survival and decreased cytotoxicity effectively at 25 ng/ml. G-CSF reduced early apoptotic (annexin V+/PI-), and late apoptotic or necrotic (annexin V+/PI+) cells, and decreased active caspase-3 immunoreactivity. G-CSF could protect human cerebral neurons following in vitro ischemia.
ISSN
0304-3940 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16298488

http://hdl.handle.net/10371/11094
DOI
https://doi.org/10.1016/j.neulet.2005.10.040
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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