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Cardiac Dysfunction After Renal Transplantation; Incomplete Resolution in Pediatric Population

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Authors
Kim, Gi Beom; Kwon, Bo Sang; Kang, Hee Gyung; Ha, Jong Won; Ha, Il Soo; Noh, Chung Il; Choi, Jung Yun; Kim, Sang Joon; Yun, Yong Soo; Bae, Eun Jung
Issue Date
2009-06-15
Publisher
Lippincott Williams & Wilkins
Citation
Transplantation 2009; 87: 1737
Keywords
Renal transplantationLeft ventricular hypertrophyVentricular dysfunctionEchocardiography
Abstract
Background. Long-term data of cardiac function after renal transplantation (RT) are limited, especially in children.
Thus, we evaluated the status of left ventricular hypertrophy and various indices of left ventricular (LV) function in
pediatric RT patients.
Methods. Blood pressure, serum biochemical profiles, electrocardiogram, and echocardiogram of 32 pediatric patients
(mean age, 15.5 4.4 years) who underwentRT5.1 2.5 years before and 29 body surface area-matched control subjects
were studied.
Results. Repolarization abnormalities shown on electrocardiogram of pre-RT patients improved significantly after RT
(QTc dispersion 50.8 37.3 to 37.4 11.9 msec, P 0.009). Left ventricular hypertrophy with increased LV mass index
of pre-RT patients regressed remarkably after RT (LV mass index 120.9 40.5 to 69.2 14.5 g/m2, P 0.001); still, LV
mass was significantly higher in RT patients than the controls (54.0 9.6 g/m2, P 0.001). Compared with the controls,
the RT patients showed diastolic dysfunction (lower E/A ratio and higher isovolumic relaxation time) and lower
myocardial performance (higher LV Tei index and weaker strain pattern). Patients who had shorter duration of non-RT
renal replacement therapy showed better LV function (lower LV Tei index and stronger strain pattern) in the long-term
follow-up.
Conclusions. Because cardiac dysfunction did not resolve after RT in pediatric population, regular evaluation for
cardiovascular function after RT is required. Early RT may also be beneficial to global LV performance after RT.
ISSN
0041-1337
Language
English
URI
http://hdl.handle.net/10371/11130
DOI
https://doi.org/10.1097/TP.0b013e3181a63f2f
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