Browse

Relative and absolute risks of cigarette smoking on major histologic types of lung cancer in Korean men

Cited 38 time in Web of Science Cited 38 time in Scopus
Authors
Yun, Young Ho; Lim, Min Kyung; Jung, Kyu Won; Bae, Jong-Myon; Park, Sang Min; Shin, Soon Ae; Lee, Jin Soo; Park, Jae-Gahb
Issue Date
2005-09-21
Publisher
American Association for Cancer Research
Citation
Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2125-30
Keywords
Adenocarcinoma/ethnology/*etiology/pathologyAdultAgedCarcinoma, Non-Small-Cell Lung/ethnology/*etiology/pathologyCarcinoma, Small Cell/ethnology/*etiology/pathologyCase-Control StudiesHumansKorea/epidemiologyLung Neoplasms/ethnology/*etiology/pathologyMaleMiddle AgedProspective StudiesRisk FactorsSmoking/*adverse effects
Abstract
OBJECTIVES: Most prospective cohort studies of lung cancer focus on the relative risk rather than the absolute risk of smoking. METHODS: This prospective study included 437,976 Korean men (cohort for the National Health Insurance Cooperation Study), > or = 40 years old, who were free of cancer and smoking-related chronic disease at the time of enrollment. Based on new incidence cases, relative risk and excess risk, and their 95% confidence intervals (95% CI), were estimated with the standard Poisson regression model after adjustment for age or other demographic factors and other confounders. RESULTS: During the 6-year follow-up period of 3,142,451 person-years, 1,357 new lung cancer cases were identified. Based on the multivariate-adjusted relative risk for current smokers, the strongest association with smoking was shown for small-cell lung cancer (relative risk, 21.7; 95% CI, 8.0-58.5) followed by squamous cell carcinoma (relative risk, 11.7; 95% CI, 7.1-19.4) and then adenocarcinoma (relative risk, 2.1; 95% CI, 1.6-2.7). In current smokers with > or = 40 pack-years of exposure, excess risk was highest for squamous cell carcinoma (excess risk, 33.8; 95% CI, 10.2-109.8) followed by adenocarcinoma (excess risk, 26.7; 95% CI, 10.3-64.4), and then small-cell carcinoma (excess risk, 16.3; 95% CI, 1.8-144.3). CONCLUSIONS: In Korean men, cigarette smoking was as important a risk factor for adenocarcinoma as it was for squamous cell and small-cell lung cancer.
ISSN
1055-9965 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16172220

http://hdl.handle.net/10371/11586
DOI
https://doi.org/10.1158/1055-9965.EPI-05-0236
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse