S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) Theses (Ph.D. / Sc.D._의학과)
The Protective Effect of Systemic Steroid Administration in Hearing Preservation after Cochlear Implantation in Guinea Pigs
기니픽 동물 모델에서 전신적 스테로이드 투여의 와우 이식 후 청력 보존 효과에 대한 고찰
- 의과대학 의학과
- Issue Date
- 서울대학교 대학원
- 학위논문 (박사)-- 서울대학교 대학원 : 의학과, 2017. 2. 이준호.
- Objectives: To determine the effectiveness of extended delivery of systemic steroids to preserve hearing in guinea pigs after cochlear implantation (CI).
Methods: Dexamethasone (4 mg/ml) was delivered parenterally via a mini-osmotic pump for either 3 or 7 days. The control group underwent CI without steroid infusion. A dummy CI electrode was inserted via a cochleostomy approach in 8-week-old guinea pigs. Auditory thresholds were assessed from tone burst auditory brainstem responses (2, 8, 16, 24, and 32 kHz) at 1 day prior to CI and 1, 4, and 12 weeks after implantation. Histologic evaluation of the cochleae was carried out.
Results: No differences were found in hearing thresholds among groups before CI. Significant hearing preservation was achieved at 8, 16, 24, and 32 kHz only in the 7-day infusion group compared with the control group at 1 week after CI. The same trend was maintained at 4 weeks (16, 24 kHz) and 12 weeks (16, 24, and 32 kHz). Histologic review of the 7-day infusion group revealed less loose connective tissue deposition, less dense fibrosis in the scala tympani and the preservation of more spiral ganglion cells, compared with the control group.
Conclusion: Seven-day administration of systemic steroids was more effective in preserving residual hearing for 12 weeks after cochlear implantation (CI) than a 3-day delivery.