Comparison of genomic characteristics of synchronous intracranial meningiomas of different histological grade

Abstract

Meningioma is the most common tumor of the central nervous system. Although several genetic studies of meningioma reveals various significant mutation related to meningioma development but still further studies are needed for confirming specific mutations. Here whole exome study was done on two meningioma samples of different histological grade obtained from a patient with multiple meningioma. This study shows that the each meningioma shows distinct tumor mutation despite from the same patient. Also both the meningioma shows distinct separate relations with different pathways. The common genetic abnormal incidence was the loss of Heterozygosity of the chromosome 22 in both tumors which maybe the cause of the tumor development and the subsequent mutations plays a role in progression towards different grades.