Publications
Detailed Information
An Assessment of the Application of Poloxamer/Sodium Alginate/CaCl2 Mixture after Abdominal Surgery in Dogs: Effects on Postoperative Adhesion and Safety : 개의 복강 수술 후 유착에 대한 Poloxamer/Sodium Alginate/CaCl2 합제의 유착 방지 효능 및 안전성 평가
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김완희 | - |
dc.contributor.author | Jina Kim | - |
dc.date.accessioned | 2017-07-19T11:31:05Z | - |
dc.date.available | 2017-07-19T11:31:05Z | - |
dc.date.issued | 2015-08 | - |
dc.identifier.other | 000000067026 | - |
dc.identifier.uri | https://hdl.handle.net/10371/133734 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 수의학과 (임상수의학 전공), 2015. 8. 김완희. | - |
dc.description.abstract | Poloxamer/sodium alginate/CaCl2 (PX/SA) mixture (Aniguard®, Genewel, South Korea) is a temperature-sensitive anti-adhesive agent used to prevent postoperative adhesion by forming a biocompatible barrier on the surface of a wound. This study investigated the safety and the ability of PX/SA mixture to prevent postoperative adhesion in dogs. Twenty dogs were divided into two experimental models: an intestine model and a uterus-urinary bladder model. Each model was further divided into two groups. Dogs in the intestine model underwent laparotomy, with multiple intestinal wall abrasions, while dogs in the uterus-urinary bladder model underwent urinary bladder wall abrasion. The control groups were treated with normal saline, and the trial groups were treated with PX/SA mixture. After 10 days, all dogs underwent a laparoscopic exploration to evaluate their abdominal status. On postoperative day 21, the abdominal adhesions were evaluated and scored by a previously validated adhesion score system. Furthermore, the extent of fibrosis and inflammation was scored according to a histopathologic examination. The adhesion scores of the trial groups were significantly reduced in both models compared to those of the control groups (P < 0.05). Furthermore, more fibrosis reactions were found on the adhesion areas in the control groups in both models. (P < 0.05) There were no statistically significant differences in inflammation between the two groups. In addition, no hepatic and renal toxicity or side effects of PX/SA mixture were observed. In conclusion, the use of PX/SA mixture effectively reduced the development of postoperative abdominal adhesions. | - |
dc.description.tableofcontents | CONTENTS
I. INTRODUCTION 1 II. MATERIALS AND METHODS 3 1. Experimental groups 3 2. Surgical procedures 4 3. Assessment of adhesions and complications 7 4. Evaluation of safety 11 5. Statistical analysis 12 III. RESULTS 13 1. Assessment of adhesions and complications 13 2. Safety evaluation 21 IV. DISCUSSION 25 V. CONCLUSION 29 VI. REFERENCES 30 VII. ABSTRACT IN KOREAN 36 | - |
dc.format | application/pdf | - |
dc.format.extent | 825381 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Aniguard® | - |
dc.subject | poloxamer | - |
dc.subject | sodium alginate | - |
dc.subject | post-operative adhesion | - |
dc.subject | prevention | - |
dc.subject.ddc | 636 | - |
dc.title | An Assessment of the Application of Poloxamer/Sodium Alginate/CaCl2 Mixture after Abdominal Surgery in Dogs: Effects on Postoperative Adhesion and Safety | - |
dc.title.alternative | 개의 복강 수술 후 유착에 대한 Poloxamer/Sodium Alginate/CaCl2 합제의 유착 방지 효능 및 안전성 평가 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | 김지나 | - |
dc.description.degree | Master | - |
dc.citation.pages | iii, 37 | - |
dc.contributor.affiliation | 수의과대학 수의학과 | - |
dc.date.awarded | 2015-08 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.