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The attenuation of neurological injury from the use of simvastatin after spinal cord ischemia-reperfusion injury in rats

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Authors
Ryu, Jung-Hee; Park, Jin-woo; Hwang, Jin-Young; Park, Seong-Joo; Kim, Jin-Hee; Sohn, Hye-Min; Han, Sung Hee
Issue Date
2018-03-27
Publisher
BioMed Central
Citation
BMC Anesthesiology, 18(1):31
Keywords
NeuroprotectionSimvastatinReperfusion injuryThoracoabdominal aortic surgery
Abstract
Background
Spinal cord ischemic injury remains a serious complication of open surgical and endovascular aortic procedures. Simvastatin has been reported to be associated with neuroprotective effect after spinal cord ischemia-reperfusion (IR) injury. The aim of this study was to determine the therapeutic efficacy of starting simvastatin after spinal cord IR injury in a rat model.

Methods
In adult Sprague-Dawley rats, spinal cord ischemia was induced using a balloon-tipped catheter placed in the descending thoracic aorta. The animals were then randomly divided into 4 groups: group A (control); group B (0.5 mg/kg simvastatin); group C (1 mg/kg simvastatin); and group D (10 mg/kg simvastatin). Simvastatin was administered orally upon reperfusion for 5 days. Neurological function of the hind limbs was evaluated for 7 days after reperfusion and recorded using a motor deficit score (MDS) (0: normal, 5: complete paraplegia). The number of normal motor neurons within the anterior horns of the spinal cord was counted after final MDS evaluation. Then, the spinal cord was harvested for histopathological examination.

Results
Group D showed a significantly lower MDS than the other groups at post-reperfusion day 1 and this trend was sustained throughout the study period. Additionally, a greater number of normal motor neurons was observed in group D than in other groups (group D 21.2 [3.2] vs. group A: 15.8 [4.2]; group B 15.4 [3.4]; and group C 15.5 [3.7]; P = 0.002).

Conclusions
The results of the current study suggest that 10 mg/kg can significantly improve neurologic outcome by attenuating neurologic injury and restoring normal motor neurons after spinal cord IR injury.
ISSN
1471-2253
Language
English
URI
http://hdl.handle.net/10371/139761
DOI
https://doi.org/10.1186/s12871-018-0496-6
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College of Medicine/School of Medicine (의과대학/대학원)Anesthesiology and Pain Medicine (마취통증의학전공)Journal Papers (저널논문_마취통증의학전공)
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