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Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013

Cited 2 time in Web of Science Cited 3 time in Scopus
Authors
Yun, Ki Wook; Choi, Eun Hwa; Lee, Hoan Jong; Kang, Jin Han; Kim, Kyung-Hyo; Kim, Dong Soo; Kim, Yae-Jean; Eun, Byung Wook; Oh, Sung Hee; Cho, Hye-Kyung; Hong, Young Jin; Kim, Kwang Nam; Kim, Nam Hee; Kim, Yun-Kyung; Lee, Hyunju; Lee, Taekjin; Kim, Hwang Min; Cho, Eun Young; Kim, Chun Soo; Park, Su Eun; Oh, Chi Eun; Jo, Dae Sun; Choi, Young Youn; Lee, Jina
Issue Date
2018-06-08
Publisher
BioMed Central
Citation
BMC Infectious Diseases, 18(1):268
Keywords
Invasive pneumococcal diseasesPneumococcal conjugate vaccineMultilocus sequence typingChildren
Abstract
Background
Understanding the population genetics of pneumococci will allow detection of changes in the prevalence of circulating genotypes and evidence for capsular switching. We aimed to analyze the genetic structure of invasive pneumococcal isolates obtained from children before and after the use of pneumococcal conjugate vaccines (PCVs) in Korea.

Methods
A total of 285 invasive pneumococcal isolates were analyzed using serotyping, multilocus sequence typing, and antimicrobial susceptibility testing. We classified the isolation year to pre-PCV7 (1995–2003; n = 70), post-PCV7 (2004–2010; n = 142), and post-PCV13 (2011–2013; n = 73) periods.

Results
Of the 10 clonal complexes (CCs), antibiotic-resistant international clones, CC320 (31.6%), CC81 (14.7%), and CC166 (6.7%) were the main complexes. Serotype 19A was the main serotype of CC320 throughout the periods. Serotypes of CC81 mainly comprised of 23F (53.3%) in pre-PCV7 period and replaced by non-vaccine types (NVTs; 6C [10%], 13 [30%], 15A [40%], and 15B/C [20%]) in post-PCV13 period. The main serotype responsible for CC166 also changed from 9 V (80%) in pre-PCV7 to NVT 11A (50%) in post-PCV13 periods. Non-susceptibility to penicillin (42.3%) was the highest in CC320, increasing from 0 to 76%.

Conclusion
The genetic structures of invasive pneumococcal isolates in Korean children have changed concomitantly with serotype after the implementation of PCVs.
ISSN
1471-2334
Language
English
URI
http://hdl.handle.net/10371/142756
DOI
https://doi.org/10.1186/s12879-018-3177-7
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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