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Evaluation of the efficacy of ivermectin against Theileria orientalis infection in grazing cattle

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Authors
Park, Jinho; Chae, Jeong-Byoung; Kim, Suhee; Yu, Do-Hyeon; Kim, Hyeon-Cheol; Park, Bae-Keun; Chae, Joon-Seok; Choi, Kyoung-Seong
Issue Date
2019-08-17
Publisher
BioMed Central
Citation
BMC Veterinary Research, 15(1):297
Keywords
GrazingHematocritIvermectinTheileria orientalis
Abstract
Background
Raising cattle on pastures is known to be beneficial for animal welfare and cost reduction. However, grazing is associated with the risk of contracting tick-borne diseases, such as theileriosis. Here, the efficacy of ivermectin against these diseases and associated clinical symptoms were evaluated.

Results
A total of 68 cattle from a grazing cattle farm were selected and divided into two groups: the control group (17 cattle) with no preventive treatment and the ivermectin-treated group (51 cattle) in which cattle were treated with pour-on ivermectin prior to grazing. The infection rates of Theileria orientalis and the red blood cell (RBC) profile (e.g., RBC count, hematocrit value, and hemoglobin concentration) were compared in the spring (before grazing) and summer (during grazing) between the two groups. Based on PCR amplification of the major piroplasm surface protein (MPSP) gene, 12 cattle were positive for T. orientalis infection. Phylogenetic analysis revealed that the isolates identified in this study consisted of three MPSP types (1, 2, and 7). The T. orientalis infection rate in the control group during grazing was 3-fold higher than that in the ivermectin-treated group. Moreover, differences in RBC parameters during grazing were greater in the control group than in the ivermectin-treated group. In particular, the hematocrit value was significantly reduced in the control group.

Conclusions
The results of this study demonstrated that ivermectin had protective effects against T. orientalis infection and RBC hemolysis in grazing cattle.
ISSN
1746-6148
Language
English
URI
http://hdl.handle.net/10371/162607
DOI
https://doi.org/10.1186/s12917-019-2042-2
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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