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Transient lymphopenia and interstitial pneumonia with endotheliitis in SARS-CoV-2-infected macaques
Cited 24 time in
Web of Science
Cited 28 time in Scopus
- Authors
- Issue Date
- 2020-11
- Publisher
- University of Chicago Press
- Citation
- Journal of Infectious Diseases, Vol.222 No.10, pp.1596-1600
- Abstract
- Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.
- ISSN
- 0022-1899
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