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Bronchoalveolar cellularity and interleukin-8 levels in measles bronchiolitis obliterans
Cited 40 time in
Web of Science
Cited 44 time in Scopus
- Authors
- Issue Date
- 2007-05-15
- Citation
- Chest. 2007 May;131(5):1454-60.
- Keywords
- Antigens, CD3/metabolism ; Antigens, CD8/metabolism ; Biopsy ; Bronchiolitis Obliterans/*etiology/*pathology ; Bronchoalveolar Lavage Fluid/*chemistry/*cytology ; Bronchoscopy ; Case-Control Studies ; Cell Count ; Child, Preschool ; Female ; Humans ; Infant ; Interleukin-8/*analysis ; Lung/immunology/pathology/radiography ; Male ; Measles/*complications/*pathology ; Neutrophils/pathology ; T-Lymphocytes/immunology/pathology ; Tomography, X-Ray Computed
- Abstract
- BACKGROUND: Measles virus infection may progress to a chronic obstructive process including bronchiolitis obliterans (BO). This study investigates pulmonary cellular profiles and interleukin (IL)-8 levels in patients with BO following the measles. METHODS: BAL fluid was obtained from 12 children with BO who had a history of measles pneumonia during an outbreak in 2000 and 2001. BAL cell counts and differentials were compared to control patients as well as BAL IL-8 levels, which were measured by enzyme-linked immunosorbent assay. Immunohistochemical staining of BAL cells and three open-lung biopsy specimens were also analyzed for T-cell surface markers CD3, CD4, and CD8. RESULTS: BAL cellular profiles were characterized by a significantly increased percentage of neutrophils in the measles BO group (median, 16.0%) compared to the control group (2.3%) [p < 0.01]. BAL IL-8 levels were also markedly increased in the measles BO group (mean +/- SD, 418.6 +/- 286.0 pg/mL) compared to the control group (92.8 +/- 126.7 pg/mL) [p < 0.01]. BAL IL-8 levels correlated significantly with neutrophil percentages in both the measles BO group (r = 0.86, p = 0.000) and the control group (r = 0.79, p = 0.007). The lymphocyte subsets were characterized by a significantly increased number of CD8+ cells, resulting in a decreased CD4/CD8 ratio in the BAL and the biopsy specimens. CONCLUSION: These results suggest that pulmonary neutrophils and IL-8, along with CD8+ T lymphocytes may play an important role in the pathogenesis of BO after measles virus infection.
- ISSN
- 0012-3692 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17494793
https://hdl.handle.net/10371/22404
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