Publications
Detailed Information
Development of 3-D nanofibrous fibroin scaffold with high porosity by electrospinning: implications for bone regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ki, Chang Seok | - |
dc.contributor.author | Park, Sook Young | - |
dc.contributor.author | Kim, Hyun Jeong | - |
dc.contributor.author | Jung, Hong-Moon | - |
dc.contributor.author | Woo, Kyung Mi | - |
dc.contributor.author | Lee, Jung Weon | - |
dc.contributor.author | Park, Young Hwan | - |
dc.date.accessioned | 2009-12-31T01:56:22Z | - |
dc.date.available | 2009-12-31T01:56:22Z | - |
dc.date.issued | 2007-11-02 | - |
dc.identifier.citation | Biotechnol Lett. 2008 Mar;30(3):405-10. Epub 2007 Nov 1. | en |
dc.identifier.issn | 0141-5492 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17973083 | - |
dc.identifier.uri | https://hdl.handle.net/10371/23985 | - |
dc.description.abstract | We made a three-dimensional (3-D) nanofibrous fibroin scaffold (NFS) with high porosity (94%) and examined its feasibility in bone regeneration. Under scanning electron microscopy, MC3T3-E1 preosteoblasts on the scaffold showed more spread on the first day after seeding compared with a 2-D scaffold. MTT assay showed significantly increased proliferation in 3-D NFS compared with 2-D NFS 7 days after seeding (P < 0.05). Western immunoblotting for activated paxillin, FAK, AKT, C-Src, and ERK1/2 antibodies showed signals from the extracellular matrix were significantly increased in 3-D NFS. Newly developed 3-D electrospun NFS may be a good candidate for use in bone regeneration. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Biocompatible Materials | en |
dc.subject | Cell Adhesion | en |
dc.subject | Cell Line | en |
dc.subject | Cell Proliferation | en |
dc.subject | Fibroins/*chemistry | en |
dc.subject | Microscopy, Electron, Scanning | en |
dc.subject | Osteoblasts/*cytology/physiology/ultrastructure | en |
dc.subject | Osteogenesis | en |
dc.subject | Porosity | en |
dc.subject | Tissue Engineering/*methods | en |
dc.subject | Bone Regeneration | - |
dc.subject | Nanostructures | - |
dc.subject | Tissue Scaffolds | - |
dc.title | Development of 3-D nanofibrous fibroin scaffold with high porosity by electrospinning: implications for bone regeneration | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 기창석 | - |
dc.contributor.AlternativeAuthor | 박숙영 | - |
dc.contributor.AlternativeAuthor | 김현정 | - |
dc.contributor.AlternativeAuthor | 정홍문 | - |
dc.contributor.AlternativeAuthor | 유경미 | - |
dc.contributor.AlternativeAuthor | 이정원 | - |
dc.contributor.AlternativeAuthor | 박영환 | - |
dc.identifier.doi | 10.1007/s10529-007-9581-5 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.