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Development of 3-D nanofibrous fibroin scaffold with high porosity by electrospinning: implications for bone regeneration

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dc.contributor.authorKi, Chang Seok-
dc.contributor.authorPark, Sook Young-
dc.contributor.authorKim, Hyun Jeong-
dc.contributor.authorJung, Hong-Moon-
dc.contributor.authorWoo, Kyung Mi-
dc.contributor.authorLee, Jung Weon-
dc.contributor.authorPark, Young Hwan-
dc.date.accessioned2009-12-31T01:56:22Z-
dc.date.available2009-12-31T01:56:22Z-
dc.date.issued2007-11-02-
dc.identifier.citationBiotechnol Lett. 2008 Mar;30(3):405-10. Epub 2007 Nov 1.en
dc.identifier.issn0141-5492 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17973083-
dc.identifier.urihttp://hdl.handle.net/10371/23985-
dc.description.abstractWe made a three-dimensional (3-D) nanofibrous fibroin scaffold (NFS) with high porosity (94%) and examined its feasibility in bone regeneration. Under scanning electron microscopy, MC3T3-E1 preosteoblasts on the scaffold showed more spread on the first day after seeding compared with a 2-D scaffold. MTT assay showed significantly increased proliferation in 3-D NFS compared with 2-D NFS 7 days after seeding (P < 0.05). Western immunoblotting for activated paxillin, FAK, AKT, C-Src, and ERK1/2 antibodies showed signals from the extracellular matrix were significantly increased in 3-D NFS. Newly developed 3-D electrospun NFS may be a good candidate for use in bone regeneration.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectBiocompatible Materialsen
dc.subject*Bone Regenerationen
dc.subjectCell Adhesionen
dc.subjectCell Lineen
dc.subjectCell Proliferationen
dc.subjectFibroins/*chemistryen
dc.subjectMicroscopy, Electron, Scanningen
dc.subject*Nanostructuresen
dc.subjectOsteoblasts/*cytology/physiology/ultrastructureen
dc.subjectOsteogenesisen
dc.subjectPorosityen
dc.subjectTissue Engineering/*methodsen
dc.subject*Tissue Scaffoldsen
dc.titleDevelopment of 3-D nanofibrous fibroin scaffold with high porosity by electrospinning: implications for bone regenerationen
dc.typeArticleen
dc.contributor.AlternativeAuthor기창석-
dc.contributor.AlternativeAuthor박숙영-
dc.contributor.AlternativeAuthor김현정-
dc.contributor.AlternativeAuthor정홍문-
dc.contributor.AlternativeAuthor유경미-
dc.contributor.AlternativeAuthor이정원-
dc.contributor.AlternativeAuthor박영환-
dc.identifier.doi10.1007/s10529-007-9581-5-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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