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Surgical treatment of malignant mediastinal neurogenic tumors in children

Cited 10 time in Web of Science Cited 16 time in Scopus
Authors
Kang, Chang Hyun; Kim, Young Tae; Jeon, Sang-Hoon; Sung, Sook-Whan; Kim, Joo Hyun
Issue Date
2007-02-20
Publisher
Elsevier
Citation
Eur J Cardiothorac Surg. 2007 Apr;31(4):725-30. Epub 2007 Feb 16.
Keywords
AdolescentChildChild, PreschoolFemaleGanglioneuroblastoma/mortality/surgeryHumansInfantInfant, NewbornMaleMediastinal Neoplasms/mortality/*surgeryNeoplasm InvasivenessNeoplasm MetastasisNeoplasm StagingNeuroblastoma/mortality/surgeryNeuroectodermal Tumors, Primitive, Peripheral/mortality/*surgeryPostoperative ComplicationsPreoperative Care/methodsRetrospective StudiesRisk FactorsTreatment Outcome
Abstract
INTRODUCTION: The aim of this study was to identify the role of surgical resection in the treatment of malignant mediastinal neurogenic tumors in children. MATERIALS AND METHODS: Thirty-eight consecutive children, who underwent surgical resection of a malignant mediastinal neurogenic tumor between 1986 and 2004, were included in this study. The tumor cell types were neuroblastoma in 23 patients (60.5%), ganglioneuroblastoma in 14 (36.8%), and malignant neuroepithelioma in 1 (2.6%). Surgery was performed for curative resection in localized tumors and salvage resection of residual mediastinal masses after chemotherapy in stage IV tumors. Of the 16 patients (42.1%) who underwent salvage resection, 14 had neuroblastoma and 2 ganglioneuroblastoma. RESULTS: Mean patient age was 3.4+/-3.0 years (1 month-13 years) and 26 patients (68.4%) were symptomatic at presentation. Adjacent structure invasion was found in eight patients (21.1%), invasion of chest wall in four, heart and vena cava in two, lung in one, and chest wall and lung in one. Complete gross resection was possible in 30 patients (78.9%) and there was no surgical mortality. Surgical morbidity occurred in 10 patients (26.3%) and Horner's syndrome was the most frequent complication (n=7). The 5-year survival was 95.2% for a localized tumor and 52.5% for a stage IV tumor (p=0.004). The significant risk factors of long-term survival were adjacent structure invasion (p=0.002) and a stage IV tumor (p=0.002) by multivariate Cox regression analysis. CONCLUSIONS: Surgical resection of localized malignant mediastinal neurogenic tumor in children showed good long-term survival, and salvage operations after chemotherapy showed acceptable long-term survival.
ISSN
1010-7940 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17306984

http://hdl.handle.net/10371/29059
DOI
https://doi.org/10.1016/j.ejcts.2007.01.026
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College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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