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Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channels
Cited 8 time in
Web of Science
Cited 13 time in Scopus
- Authors
- Issue Date
- 2007-05-09
- Publisher
- Springer-Verlag
- Citation
- Pflugers Arch. 2007 Sep;454(6):1023-30. Epub 2007 May 8.
- Keywords
- Acute Disease ; Adenine/analogs & derivatives/pharmacology ; Animals ; Anoxia/*physiopathology ; Blood Pressure/physiology ; Carbazoles/pharmacology ; Coronary Circulation/*physiology ; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors ; Cyclic GMP/analogs & derivatives/pharmacology ; Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors ; Enzyme Inhibitors/pharmacology ; Female ; Glyburide/pharmacology ; Indoles/pharmacology ; Male ; Potassium Channel Blockers/pharmacology ; Potassium Channels, Inwardly Rectifying/drug effects/*physiology ; Pyrroles/pharmacology ; Rabbits ; Signal Transduction/physiology ; Vasodilation/*physiology
- Abstract
- We examined the effects of acute hypoxia on vascular tone and coronary blood flow (CBF) in rabbit coronary arteries. In the pressurized arterial preparation of small arteries (<100 mum) and the Langendorff-perfused rabbit hearts, hypoxia induced coronary vasodilation and increased CBF in the presence of glibenclamide (K(ATP) channel blocker), Rp-8-Br-PET-cGMPs [cyclic guanosine monophosphate (cGMP)-dependent protein kinase inhibitor, Rp-cGMPs], and methionyl transfer RNA synthetase (MRS) 1334 (adenosine A(3) receptor inhibitor); these increases were inhibited by the inward rectifier K(+) (Kir) channel inhibitor, Ba(2+). These effects were blocked by the adenylyl cyclase inhibitor SQ 22536 and by the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) inhibitors Rp-8-CPT-cAMPs (Rp-cAMPs) and KT 5720. However, cGMP-dependent protein kinase was not involved in the hypoxia-induced increases of the vascular diameter and CBF. In summary, our results suggest that acute hypoxia can induce the opening of Kir channels in coronary artery that has small diameter (<100 mum) by activating the cAMP and PKA signalling pathway, which could contribute to vasodilation and, therefore, increased CBF.
- ISSN
- 0031-6768 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17486361
https://hdl.handle.net/10371/29351
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