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Chemokine and cytokine production in susceptible C3H/HeN mice and resistant BALB/c mice during Orientia tsutsugamushi infection
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- Authors
- Issue Date
- 2005-06-21
- Publisher
- Wiley-Blackwell
- Citation
- Microbiol Immunol. 2005;49(6):551-7.
- Keywords
- Animals ; Chemokines/*biosynthesis/genetics/metabolism ; Cytokines/*biosynthesis/genetics ; Interleukin-10/biosynthesis ; Interleukin-12/biosynthesis ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Scrub Typhus/etiology/genetics/*immunology ; Tumor Necrosis Factor-alpha/biosynthesis/genetics ; Orientia tsutsugamushi
- Abstract
- To understand the pathogenesis of scrub typhus, we examined chemokine and cytokine production in susceptible (C3H/HeN) and resistant (BALB/c) mice after infection with O. tsutsugamushi Gilliam. C3H/HeN mice produced high levels of chemokines macrophage inflammatory proteins 1 alpha (MIP-1 alpha ), MIP-2, monocyte chemoattractant protein 1 (MCP-1), and cytokines gamma-interferon (IFN-gamma ), interleukin-12 (IL-12), IL-10, and tumor necrosis factor alpha (TNF-alpha ) in response to O. tsutsugamushi infection, compared to BALB/c mice. Chemokine profiles in infected mice correlated well with the kinetics of inflammatory cell infiltration. Hyperproduction of chemokines and cytokines was observed in another susceptible-infection model (BALB/c-Karp). These results suggest that hyperproduction of chemokines and cytokines are associated with susceptibility during O. tsutsugamushi infection.
- ISSN
- 0385-5600 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15965303
https://hdl.handle.net/10371/29821
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